Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Aug 13;8(1):359.
doi: 10.1038/s41420-022-01157-4.

LncRNA in tumorigenesis of non-small-cell lung cancer: From bench to bedside

Qin Hu  1   2 , Huiyun Ma  1   2 , Hongyu Chen  1   2 , Zhouwei Zhang  1   2 , Qun Xue  3
Affiliations
Review

LncRNA in tumorigenesis of non-small-cell lung cancer: From bench to bedside

Qin Hu et al. Cell Death Discov. .

Abstract

Lung cancer has been one of the leading causes of cancer-related death worldwide, and non-small-cell lung cancer (NSCLC) accounts for the majority of lung cancer morbidity, yet the pathogenesis of NSCLC has not been fully elucidated. Recently, long-chain non-coding RNA (lncRNA) has attracted widespread attention. LncRNA is a type of non-coding RNA whose transcript length exceeds 200 nucleotides. After constant research, academics updated their understanding of lncRNA, especially its role in the biological processes of cancer cells, including epigenetic regulation, cell proliferation, and cell differentiation. Notably, examination of lncRNAs could serve as potential hallmarks for clinicopathological features, long-term prognosis, and drug sensitivity. Therefore, it is necessary to explore the functions of lncRNA in NSCLC and innovate potential strategies against NSCLC based on lncRNA-related research. Herein, we reviewed the functions of lncRNA in the occurrence, diagnosis, treatment, and prognosis of NSCLC, which not only help promote a comprehensive view of lncRNA in NSCLC, but also shed light on the potential of lncRNA-based diagnosis and treatment of NSCLC.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Schematic of LncRNA-based regimen in NSCLC.
Fig. 2
Fig. 2
Schematic of LncRNAs interact with microRNAs regimen in NSCLC.
Fig. 3
Fig. 3
Schematic of LncRNAs regulate signaling pathways regimen in NSCLC.
Fig. 4
Fig. 4
Schematic of LncRNA and Lung cancer stem cells regimen in NSCLC.
See this image and copyright information in PMC

References

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: Cancer J Clin. 2018;68:394–424. - PubMed
    1. Guo H, Chang Z, Wu J, Li W. Air pollution and lung cancer incidence in China: Who are faced with a greater effect? Environ Int. 2019;132:105077. doi: 10.1016/j.envint.2019.105077. - DOI - PubMed
    1. Chen W, Zheng R, Zhang S, Zeng H, Zuo T, Xia C, et al. Cancer incidence and mortality in China in 2013: An analysis based on urbanization level. Chin J Cancer Res = Chung-kuo yen cheng yen chiu. 2017;29:1–10. doi: 10.21147/j.issn.1000-9604.2017.01.01. - DOI - PMC - PubMed
    1. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA: Cancer J Clin. 2022;72:7–33. - PubMed
    1. Allemani C, Weir HK, Carreira H, Harewood R, Spika D, Wang XS, et al. Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2) Lancet. 2015;385:977–1010. doi: 10.1016/S0140-6736(14)62038-9. - DOI - PMC - PubMed