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. 2022 Aug 13;23(1):774.
doi: 10.1186/s12891-022-05711-0.

Genetic variants of interleukin 1B and 6 are associated with clinical outcome of surgically treated lumbar degenerative disc disease

Adam Biczo  1   2 , Ferenc Bereczki  1   2 , Kristóf Koch  1   2 , Peter Pal Varga  2 ; Genodisc Consortium; Aron Lazary  3   4
Collaborators, Affiliations

Genetic variants of interleukin 1B and 6 are associated with clinical outcome of surgically treated lumbar degenerative disc disease

Adam Biczo et al. BMC Musculoskelet Disord. .

Abstract

Background: Successfully surgically treating degenerative disc diseases can be challenging to the spine surgeons, the long-term outcome relies on both the physical and mental status of the patient before and after treatment. Numerous studies underlined the role of inflammatory cytokines - like interleukin 1B and 6 - in the development of chronic diseases such as failed back surgery syndrome (FBSS) and major depressive disorder (MDD) which alter the outcome after spinal surgery. Our aim was to evaluate the associations of IL6 and IL1B gene polymorphisms with the long-term outcome of degenerative lumbar spine surgeries.

Methods: An international genetical database (GENODISC) was combined with our institute's clinical database to create a large pool with long term follow up data. Altogether 431 patient's data were analysed. Patient reported outcome measures and surgical outcome was investigated in association with IL1B and IL6 SNPs with the help of 'SNPassoc' R genome wide association package.

Results: Interleukin 1B variants analysis confirmed association with improvement of pain after surgery on individual SNP level and on haplotype level, moreover relationship with patient reported outcome and preoperative level of depression was found on individual SNP level. IL6 variants were associated with preoperative depression, somatization and with subsequent surgery.

Conclusion: Understanding the complexity of spinal surgery patients' long-term well-being is crucial in effectively treating chronic debilitating somatic diseases and the associated mental illnesses. Further studies should investigate more comprehensively the linkage of chronic physical and mental illnesses focusing on their simultaneous treatment.

Keywords: Degenerative disc diseases; Interleukins; Long term outcome; Single nucleotide polymorphism.

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Conflict of interest statement

The authors declare they have no financial interests.

Figures

Fig. 1
Fig. 1
Linkage disequilibrium (LD) map of IL1B (A) and IL6 (B) SNPs. Squares are colored darker if the |D’| value is high, that is, LD is strong. Empty dark squares mean |D’|=1, that is, complete LD between two single nucleotide polymorphisms
Fig. 2
Fig. 2
Preoperative pain in microdiscectomy subgroup (mean ±SD)
See this image and copyright information in PMC

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