Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2022 Aug;43(8):891-898.
doi: 10.15537/smj.2022.43.8.20220424.

Effects of different fresh gas flows on carboxyhemoglobin levels: non-invasive carbon monoxide monitoring: A randomized clinical trial

Bengü G Köksal  1 , Gamze Küçükosman  1 , Pişkin Özcan  1 , Çağdaş Baytar  1 , Keziban Bollucuoğlu  1 , Rahşan D Okyay  1 , Hilal Ayoğlu  1
Affiliations
Randomized Controlled Trial

Effects of different fresh gas flows on carboxyhemoglobin levels: non-invasive carbon monoxide monitoring: A randomized clinical trial

Bengü G Köksal et al. Saudi Med J. 2022 Aug.

Abstract

Objectives: To observe the effect of different fresh gas flows (FGF) on carboxyhemoglobin (COHb) levels non-invasively and continuously and to determine the contribution of the smoking status to intraoperative carbon monoxide (CO) accumulation and respiratory complications.

Methods: A total of 64 patients were included in the study. Carboxyhemoglobin level was monitored non-invasively from the fingertip. Patients were divided into 2 according to the FGF as low-flow anesthesia (LFA; Group L) and high flow anesthesia (Group H). Each group was divided again into 2 groups as smokers and non-smokers. Carboxyhemoglobin and and the respiratory complications that occurred in the post-anesthesia care unit were recorded.

Results: The mean COHb values were significantly higher in Group L between 30th and 210th minutes. Furthermore, in Group L, intraoperative COHb levels were significantly higher in smokers compared to non-smokers in all periods. In group H, no difference was observed between smokers and non-smokers in terms of COHb levels after 60 minutes and also preoperative COHb levels of the patients developed respiratory complication was higher.

Conclusion: If the CO2 absorbent is properly preserved in patients who are administered LFA, there will be no risk of CO accumulation even in chronic smokers.ClinicalTrials.gov REG. No.: NCT04832256.

Keywords: anesthesia; carbon monoxide; carboxyhemoglobin; cigarette smoking.

PubMed Disclaimer

Figures

Figure 1
Figure 1
- Flow diagram of the study (CONSORT).
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Baum JA, Aitkenhead AR. Low-flow anaesthesia. Anaesthesia 1995; 50: 37–44. - PubMed
    1. Baum J.A., Anaesthetic methods with reduced fresh gas flows. In: Baum JA (editor). Low flow anaesthesia. The theory and practise of low flow, minimal flow and closed system anaesthesia, 2nd ed. Oxford, Boston, UK: Butterworth-Heinemann; 2001. pp. 54–73.
    1. Berry PD, Sessler DI, Larson MD. Severe carbon monoxide poisoning during desflurane anesthesia. Anesthesiology 1999; 90: 613–616. - PubMed
    1. Iqbal S, Clower JH, Hernandez SA, Damon SA, Yip FY. A review of disaster-related carbon monoxide poisoning: surveillance, epidemiology, and opportunities for prevention. Am J Public Health 2012; 102: 1957–1963. - PMC - PubMed
    1. Thom SR. Carbon monoxide pathophysiology and treatment. In: Physiology and medicine of hyperbaric oxygen therapy. ScienceDirect 2008; 15: 321–347.

Publication types

Associated data