The 2022 World Health Organization Classification of Tumors of the Urinary System and Male Genital Organs-Part B: Prostate and Urinary Tract Tumors

doi:10.1016/j.eururo.2022.07.002

Review

. 2022 Nov;82(5):469-482.

doi: 10.1016/j.eururo.2022.07.002. Epub 2022 Aug 11.

The 2022 World Health Organization Classification of Tumors of the Urinary System and Male Genital Organs-Part B: Prostate and Urinary Tract Tumors

George J Netto¹, Mahul B Amin², Daniel M Berney³, Eva M Compérat⁴, Anthony J Gill⁵, Arndt Hartmann⁶, Santosh Menon⁷, Maria R Raspollini⁸, Mark A Rubin⁹, John R Srigley¹⁰, Puay Hoon Tan¹¹, Satish K Tickoo¹², Toyonori Tsuzuki¹³, Samra Turajlic¹⁴, Ian Cree¹⁵, Holger Moch¹⁶

Affiliations

¹ Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: gnetto@uabmc.edu.
² Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Urology, USC Keck School of Medicine, Los Angeles, CA, USA.
³ Barts Cancer Institute, Queen Mary University of London, London, UK; Department of Cellular Pathology, Barts Health NHS Trust, London, UK.
⁴ Department of Pathology, Medical University of Vienna, General Hospital of Vienna, Vienna, Austria.
⁵ Sydney Medical School, University of Sydney, Sydney, Australia; NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital St Leonards, Sydney, Australia; Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital St Leonards, Sydney, Australia.
⁶ Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
⁷ Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
⁸ Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy.
⁹ Department for BioMedical Research (DBMR), Bern Center for Precision Medicine (BCPM), University of Bern and Inselspital, Bern, Switzerland.
¹⁰ Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
¹¹ Division of Pathology, Singapore General Hospital, Singapore.
¹² Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
¹³ Department of Surgical Pathology, AichiMedicalUniversity Hospital, Nagakut, Japan.
¹⁴ The Francis Crick Institute and The Royal Marsden NHS Foundation Trust, London, UK.
¹⁵ International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.
¹⁶ Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.

PMID: 35965208
DOI: 10.1016/j.eururo.2022.07.002

Review

The 2022 World Health Organization Classification of Tumors of the Urinary System and Male Genital Organs-Part B: Prostate and Urinary Tract Tumors

George J Netto et al. Eur Urol. 2022 Nov.

. 2022 Nov;82(5):469-482.

doi: 10.1016/j.eururo.2022.07.002. Epub 2022 Aug 11.

Authors

Affiliations

¹ Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: gnetto@uabmc.edu.
² Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Urology, USC Keck School of Medicine, Los Angeles, CA, USA.
³ Barts Cancer Institute, Queen Mary University of London, London, UK; Department of Cellular Pathology, Barts Health NHS Trust, London, UK.
⁴ Department of Pathology, Medical University of Vienna, General Hospital of Vienna, Vienna, Austria.
⁵ Sydney Medical School, University of Sydney, Sydney, Australia; NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital St Leonards, Sydney, Australia; Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital St Leonards, Sydney, Australia.
⁶ Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
⁷ Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
⁸ Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy.
⁹ Department for BioMedical Research (DBMR), Bern Center for Precision Medicine (BCPM), University of Bern and Inselspital, Bern, Switzerland.
¹⁰ Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
¹¹ Division of Pathology, Singapore General Hospital, Singapore.
¹² Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
¹³ Department of Surgical Pathology, AichiMedicalUniversity Hospital, Nagakut, Japan.
¹⁴ The Francis Crick Institute and The Royal Marsden NHS Foundation Trust, London, UK.
¹⁵ International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.
¹⁶ Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.

PMID: 35965208
DOI: 10.1016/j.eururo.2022.07.002

Abstract

The 2022 World Health Organization (WHO) classification of the urinary and male genital tumors was recently published by the International Agency for Research on Cancer. This fifth edition of the WHO "Blue Book" offers a comprehensive update on the terminology, epidemiology, pathogenesis, histopathology, diagnostic molecular pathology, and prognostic and predictive progress in genitourinary tumors. In this review, the editors of the fifth series volume on urologic and male genital neoplasms present a summary of the salient changes introduced to the classification of tumors of the prostate and the urinary tract.

Keywords: Carcinoma; Classification; Prostate; Urinary tract; World Health Organization.

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The 2022 World Health Organization Classification of Tumors of the Urinary System and Male Genital Organs-Part B: Prostate and Urinary Tract Tumors

Affiliations

The 2022 World Health Organization Classification of Tumors of the Urinary System and Male Genital Organs-Part B: Prostate and Urinary Tract Tumors

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