Association of hyperuricemia with apolipoprotein AI and atherogenic index of plasma in healthy Chinese people: a cross-sectional study

Abstract

Background: The atherogenic index of plasma (AIP) is a predictor for cardiovascular diseases (CVD), while hyperuricemia is an independent risk factor for a variety of CVD. Apolipoprotein AI has been found to be a protective factor for CVD. However, the role of APO AI in the association between plasma uric acid and AIP among healthy Chinese people needs to be further explored.

Aims: To evaluate the relationship between blood uric acid and AIP level in healthy Chinese people. To evaluate the relationship between blood uric acid and Apolipoprotein AI in healthy Chinese people.

Method: A total of 3501 normal and healthy subjects who had physical examinations were divided into the hyperuricemia (HUA) group and the normouricemia (NUA) group.

Result: The AIP of HUA group was significantly higher than that of NUA group [0.17±0.30 vs. -0.08±0.29]. Apo AI (1.33 ± 0.21 vs. 1.47 ± 0.26 g/l) and HDL-c (1.12 ± 0.27 vs. 1.36 ± 0.33 mmol/l) were significantly lower in the HUA group than in the NUA group. LDL-C (2.81 ± 0.77 vs. 2.69 ± 0.73 mmol/l), Apo B (0.96 ± 0.20 vs. 0.89 ± 0.20 g/l), FBG (5.48 ± 0.48 vs. 5.36 ± 0.48 mmol/l) and HOMA-IR [2.75 (1.92-3.91) vs. 2.18 (1.50-3.12)] was significantly higher in HAU group than the NUA group. Increases in plasma UA were associated with increases in AIP (β = 0.307, p < 0.01) and decreases in Apo AI (β = - 0.236, p < 0.01).

Conclusion: Hyperuricemia is an independent risk factor for high AIP level. Inhibition of Apolipoprotein AI may be one of the mechanisms of UA which is involved in the progression of cardiovascular disease.

Keywords: AIP; Apo AI; Hyperuricemia.

Fig. 1

Comparison of lipid metabolism indices between HUA and NUA group. Bar graph of Lipid metabolism indices (A HDL-c; B Apo AI; C LDL-c; D Apo-B) mean value with SD intervals between NUA and HUA groups. *p < 0.05, **p < 0.01. UA uric acid, HDL-c high-density lipoprotein cholesterol, Apo AI apolipoprotein A1, LDL-c low-density lipoprotein cholesterol, Apo B apolipoprotein B

Fig. 2

Comparison of glucose metabolism indices between HUA and NUA group. Bar graph of glucose metabolism indices (A FBG; B INS; C HOMA-IR; D HOMA-β) mean value with SD intervals or median with quartiles between NUA and HUA groups. *p < 0.05, **p < 0.01. FBG Fasting blood glucose, INS insulin, HOMA-IR homeostasis model assessment of insulin resistance, HOMA-β homeostasis model assessment of β-cell function

Fig. 3

The correlation between plasma UA and AIP. Correlation analysis was used to prove the linear relationship between plasma UA and AIP. Plasma UA was positively correlated with AIP

Fig. 4

Correlation between plasma UA and the levels of Apo AI and HDL-c. Correlation analysis was used to prove the linear relationship between plasma UA and the levels of Apo AI (A) and HDL-c (B). Plasma UA was negatively correlated with Apo AI and HDL-C