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. 2022 Jul 31:2022:9983071.
doi: 10.1155/2022/9983071. eCollection 2022.

Correlation of TET-2 Levels with Disease Evaluation in AMI Patients

Qinglei Wang  1 , Shan Fu  1 , Shucheng Li  1 , Xiansheng Huang  1 , Hong Wang  1
Affiliations

Correlation of TET-2 Levels with Disease Evaluation in AMI Patients

Qinglei Wang et al. Contrast Media Mol Imaging. .

Abstract

Objective: To investigate the expression levels of Ten-Eleven Translocation-2 (TET-2) in patients with acute myocardial infarction (AMI) and correlations of TET-2 levels with disease severity.

Methods: A total of 150 patients with confirmed AMI were included in this study. According to the number of coronary artery lesions, the patients were divided into a single lesion group, two lesion group, and three lesion group. According to the Gensini scores, these patients were also assigned into three groups: the low-risk group, middle-risk group, and high-risk group. 150 patients without AMI confirmed by coronary angiography were included in the control group in the same period. TET-2 and cardiac troponin T (cTNT) levels were detected by ELISA analysis and compared among different groups. Pearson's correlation analysis was used to evaluate the correlations of TET-2 levels and cTNT levels/Gensini scores. The levels of TET-2 in AMI patients increased remarkably with the increase of disease severity. Patients in the single lesion group or low-risk group had the lowest levels of TET-2. Pearson correlation analysis indicated that TET-2 levels were positively associated with cTNT levels and Gensini scores, respectively (all P < 0.001).

Conclusion: The levels of TET-2 were upregulated in AMI patients and positively correlated with cTNT levels or Gensini scores, suggesting that the examination of TET-2 expression levels could be exploited for predicting the disease severity.

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Conflict of interest statement

The authors declare that they have no conflicts of interest regarding this work.

Figures

Figure 1
Figure 1
Comparison of serum levels of TET-2 among different groups. (a) Different lesion groups, compared with a single lesion,  ∗P < 0.05 and compared with two lesions, #P < 0.05; (b) different risk groups, compared with the low-risk group,  ∗P < 0.05 and compared with the middle-risk group, #P < 0.05.
Figure 2
Figure 2
The correlation analysis between TET-2 and cTNT/Gensini scores. (a) TET-2 levels were positively associated with cTNT levels. (b) TET-2 levels were positively associated with Gensini scores.
See this image and copyright information in PMC

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