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Case Reports
. 2021 Dec 28:18:44.
doi: 10.18502/fid.v18i44.8340. eCollection 2021.

Central Odontogenic Fibroma Accompanied by a Central Giant Cell Granuloma-Like Lesion: Report of a Case and Review of Literature

Monir Moradzadeh Khiavi  1 , Abbas Karimi  2   3 , Hassan Mirmohammad Sadeghi  4 , Samira Derakhshan  1 , Seyed Mobin Tafreshi  5 , Samar Jalali  5
Affiliations
Case Reports

Central Odontogenic Fibroma Accompanied by a Central Giant Cell Granuloma-Like Lesion: Report of a Case and Review of Literature

Monir Moradzadeh Khiavi et al. Front Dent. .

Abstract

Central giant cell granuloma (CGCG) is a benign non-neoplastic intraosseous lesion mainly found in the anterior mandible. It is characterized by multinucleated giant cells, representing osteoclasts or macrophages. Central odontogenic fibroma (COF) is an uncommon benign lesion of the jaws. It originates from the odontogenic ectomesenchyme. In rare cases, COF may accompany a CGCG. To date, 49 cases of COF accompanied by CGCG-like lesions have been reported in the literature. In this paper, we present another case of COF-CGCG in a 46-year-old female. The lesion was located in the posterior mandible. Excisional biopsy was carried out, and histopathological analysis revealed multinucleated giant cells with numerous strands of odontogenic epithelium. A literature review of previously reported cases was also performed.

Keywords: Fibroma; Granuloma, Giant Cell; Odontogenic Tumors.

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Figures

Fig. 1
Fig. 1
Panoramic radiograph showing a radiolucent lesion in the left posterior mandible, between second premolar and first molar
Fig. 2
Fig. 2
Cone-beam computed tomography scan demonstrating a unilocular radiolucency with buccal expansion and perforation: (A) axial and (B) sagittal views
Fig. 3
Fig. 3
Nests of odontogenic epithelium (arrows) and multinucleated giant cells (arrowheads) with a low magnification (x20) showing the two lesions relative to each other
Fig. 4
Fig. 4
Immunoreactivity of odontogenic epithelium for pan-cytokeratin (A, x40) and giant cells for CD68 (B, x40)
See this image and copyright information in PMC

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