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. 2021 Sep 29:18:35.
doi: 10.18502/fid.v18i35.7339. eCollection 2021.

Effect of Casein Phosphopeptide Amorphous Calcium Phosphate and Xylitol Chewing Gums, and Probiotic Yogurt on Periodontal Parameters: A Randomized Clinical Trial

Maryam Mehrabkhani  1 , Iman Parisay  1 , Niayesh Mastoory  2 , Vajihe Barati Doghai  1
Affiliations

Effect of Casein Phosphopeptide Amorphous Calcium Phosphate and Xylitol Chewing Gums, and Probiotic Yogurt on Periodontal Parameters: A Randomized Clinical Trial

Maryam Mehrabkhani et al. Front Dent. .

Abstract

Objectives: This study aimed to assess the effect of casein phosphopeptide amorphous calcium phosphate (CPP-ACP) and xylitol chewing gums, and probiotic yogurt, as chemical plaque control strategies, on periodontal parameters. Materials and Methods: This randomized clinical trial evaluated 120 eligible dental students that were randomly divided into four groups (n=30) for use of (I) CPP-ACP chewing gum, (II) xylitol chewing gum, (III) probiotic yogurt, and (IV) chlorhexidine (CHX) mouthwash. The oral hygiene index-simplified (OHI-S), Silness and Loe gingival index (GI), and Silness and Loe modified plaque index (PI) were measured before and on days 15 and 30 after using the products. Paired t-test or its non-parametric equivalent was used to analyze the parameters after the intervention compared with baseline. The study groups were compared using one-way ANOVA or its non-parametric equivalent. Results: The OHI-S did not change over time, and most participants had a good OHI-S. The CHX group had the most favorable, and the probiotic yogurt group had the least favorable GI. Pairwise comparisons of the groups did not reveal a significant difference in GI between the CPP-ACP gum and CHX groups (P>0.05). CHX caused the greatest improvement in PI, with significant differences with other groups. Conclusion: CHX was the most effective for improvement of periodontal parameters followed by CPP-ACP, which showed better results compared with other groups.

Keywords: Casein Phosphopeptide-Amorphous Calcium Phosphate Nanocomplex; Chlorhexidine; Periodontal Diseases; Probiotics; Xylitol.

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Figures

Fig. 1
Fig. 1
Flowchart of the study
Fig. 2
Fig. 2
Frequency distribution of oral hygiene index-simplified scores of the study groups at different time points
Fig. 3
Fig. 3
Silness and Loe gingival index of the study groups at different time points
Fig. 4
Fig. 4
Plaque index of the study groups at different time points
See this image and copyright information in PMC

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