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. 2021 Sep 29:18:35.
doi: 10.18502/fid.v18i35.7339. eCollection 2021.

Effect of Casein Phosphopeptide Amorphous Calcium Phosphate and Xylitol Chewing Gums, and Probiotic Yogurt on Periodontal Parameters: A Randomized Clinical Trial

Maryam Mehrabkhani  1 , Iman Parisay  1 , Niayesh Mastoory  2 , Vajihe Barati Doghai  1
Affiliations

Effect of Casein Phosphopeptide Amorphous Calcium Phosphate and Xylitol Chewing Gums, and Probiotic Yogurt on Periodontal Parameters: A Randomized Clinical Trial

Maryam Mehrabkhani et al. Front Dent. .

Abstract

Objectives: This study aimed to assess the effect of casein phosphopeptide amorphous calcium phosphate (CPP-ACP) and xylitol chewing gums, and probiotic yogurt, as chemical plaque control strategies, on periodontal parameters. Materials and Methods: This randomized clinical trial evaluated 120 eligible dental students that were randomly divided into four groups (n=30) for use of (I) CPP-ACP chewing gum, (II) xylitol chewing gum, (III) probiotic yogurt, and (IV) chlorhexidine (CHX) mouthwash. The oral hygiene index-simplified (OHI-S), Silness and Loe gingival index (GI), and Silness and Loe modified plaque index (PI) were measured before and on days 15 and 30 after using the products. Paired t-test or its non-parametric equivalent was used to analyze the parameters after the intervention compared with baseline. The study groups were compared using one-way ANOVA or its non-parametric equivalent. Results: The OHI-S did not change over time, and most participants had a good OHI-S. The CHX group had the most favorable, and the probiotic yogurt group had the least favorable GI. Pairwise comparisons of the groups did not reveal a significant difference in GI between the CPP-ACP gum and CHX groups (P>0.05). CHX caused the greatest improvement in PI, with significant differences with other groups. Conclusion: CHX was the most effective for improvement of periodontal parameters followed by CPP-ACP, which showed better results compared with other groups.

Keywords: Casein Phosphopeptide-Amorphous Calcium Phosphate Nanocomplex; Chlorhexidine; Periodontal Diseases; Probiotics; Xylitol.

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Figures

Fig. 1
Fig. 1
Flowchart of the study
Fig. 2
Fig. 2
Frequency distribution of oral hygiene index-simplified scores of the study groups at different time points
Fig. 3
Fig. 3
Silness and Loe gingival index of the study groups at different time points
Fig. 4
Fig. 4
Plaque index of the study groups at different time points
See this image and copyright information in PMC

References

    1. Nozawa A, Oshima H, Togawa N, Nozaki T, Murakami S. Development of Oral Care Chip, a novel device for quantitative detection of the oral microbiota associated with periodontal disease. PLoS One. 2020 Feb;15(2):e0229485. - PMC - PubMed
    1. Mishra R, Chandrashekar KT, Tripathi VD, Hazari A, Sabu BS, Sahu A. Comparative evaluation of efficacy of 0.2% sodium hypochlorite (Hi Wash) mouthwash with 0.2% chlorhexidine mouthwash on plaque-induced gingivitis: A clinical trial. J Indian Soc Periodontol. 2019 Nov;23(6):534–8. - PMC - PubMed
    1. Badar SB, Zafar K, Ghafoor R, Khan FR. Comparative evaluation of Chlorhexidine, Metronidazole and combination gels on gingivitis: A randomized clinical trial. Int J Surg Protoc. 2019 Apr;14:30–3. - PMC - PubMed
    1. Abdulkareem AA, Al Marah ZA, Abdulbaqi HR, Alshaeli AJ, Milward MR. A randomized double-blind clinical trial to evaluate the efficacy of chlorhexidine, antioxidant, and hyaluronic acid mouthwashes in the management of biofilm-induced gingivitis. Int J Dent Hyg. 2020 Aug;18(3):268–77. - PubMed
    1. Khairnar MR, Karibasappa GN, Dodamani AS, Vishwakarma P, Naik RG, Deshmukh MA. Comparative assessment of Cranberry and Chlorhexidine mouthwash on streptococcal colonization among dental students: A randomized parallel clinical trial. Contemp Clin Dent. 2015 Jan;6(1):35–9. - PMC - PubMed

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