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Case Reports
. 2022 Aug 9;13(8):20542704221086162.
doi: 10.1177/20542704221086162. eCollection 2022 Aug.

An unwell patient with Parkinson's disease: Hyperpyrexia syndrome in a heatwave

Elizabeth Mooney  1 , Matthew D Smith  1   2 , Emily J Henderson  1   2
Affiliations
Case Reports

An unwell patient with Parkinson's disease: Hyperpyrexia syndrome in a heatwave

Elizabeth Mooney et al. JRSM Open. .

Abstract

Hyperpyrexia syndrome in Parkinson's disease (PD) is a medical emergency requiring prompt action. This can be precipitated by numerous provoking factors, in particular withdrawal of dopaminergic medication. We report a case of a patient with PD presenting with confusion, dramatic worsening of PD symptoms and pyrexia in the context of a heatwave, potentially mediating its effect through dehydration and impaired medication absorption. Precipitous cooling and conversion of dopaminergic medication to a rotigotine patch due to drowsiness led to her rapid improvement. The possibility of infection was covered however no source of infection or evidence of inflammatory response was found, but remained an important differential. This case highlights the importance of recognising and managing hyperpyrexia syndrome in PD and the possibility of uncharacteristically hot weather being a cause.

Keywords: Parkinson’s disease; heatwave; hyperpyrexia.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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References

    1. Azar J, Elinav H, Safadi R, Soliman M. Malignant deep brain stimulator withdrawal syndrome. BMJ Case Rep 2019; 12(5): e229122. - PMC - PubMed
    1. Mizuno Y, Takubo H, Mizuta E, Kuno S. Malignant syndrome in Parkinson’s disease: concept and review of the literature. Park. Relat. Disord 2003; 9: 3–9. - PubMed
    1. Gaig C, Martí MJ, Tolosa E, Gómez-Choco MJ, Amaro S. Parkinsonism-hyperpyrexia syndrome not related to antiparkinsonian treatment withdrawal during the 2003 summer heat wave [1]. J Neurol 2005; 252: 1116–1119. - PubMed
    1. Takubo H, Harada T, Hashimoto T, et al. A collaborative study on the malignant syndrome in Parkinson’s disease and related disorders. Park Relat Disord 2003; 9(Suppl 1): 31–41. - PubMed
    1. Newman EJ, Grosset DG, Kennedy PGE. The parkinsonism-hyperpyrexia syndrome. Neurocrit Care 2009; 10: 136–140. - PubMed

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