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. 2022 Jul 19:13:879890.
doi: 10.3389/fendo.2022.879890. eCollection 2022.

Global, Regional and National Burden of Cancers Attributable to High Fasting Plasma Glucose in 204 Countries and Territories, 1990-2019

Saeid Safiri  1   2 , Seyed Aria Nejadghaderi  3   4 , Nahid Karamzad  5 , Jay S Kaufman  6 , Kristin Carson-Chahhoud  7   8 , Nicola Luigi Bragazzi  9 , Mark J M Sullman  10   11 , Mohammad Reza Beyranvand  4 , Mohammad Ali Mansournia  12 , Amir Almasi-Hashiani  13 , Gary S Collins  14   15 , Ali-Asghar Kolahi  4
Affiliations

Global, Regional and National Burden of Cancers Attributable to High Fasting Plasma Glucose in 204 Countries and Territories, 1990-2019

Saeid Safiri et al. Front Endocrinol (Lausanne). .

Abstract

Background: To report the burden of cancers attributable to high fasting plasma glucose (HFPG) by sex, age, location, cancer type and Socio-demographic Index (SDI) over the period 1990 to 2019 for 204 countries and territories.

Methods: Using the Comparative Risk Assessment approach of Global Burden of Disease (GBD) study 2019, the burden of cancers attributable to HFPG was reported in 1990 and 2019.

Results: Globally, in 2019 there were an estimated 419.3 thousand cancer deaths (95% UI: 115.7 to 848.5) and 8.6 million cancer DALYs (2.4 to 17.6) attributable to HFPG. By sex, 4.6 (1.1 to 9.9) and 4.0 (1.1 to 8.4) million global cancer DALYs were attributable to HFPG in men and women, respectively. The global age-standardized death and DALY rates of cancers attributable to HFPG (per 100,000) have increased by 27.8% (20.5 to 38.7%) and 24.5% (16.4 to 35.6%), respectively, since 1990. High-income North America (9.5 [2.7 to 18.8]) and Eastern Sub-Saharan Africa (2.0 [0.5 to 4.2]) had the highest and lowest regional age-standardized death rates, respectively, for cancers attributable to HFPG. In 2019, the global number of attributable cancer DALYs were highest in 65-69 age group. Moreover, there was an overall positive association between SDI and the regional age-standardized DALY rate for HFPG-attributable cancers.

Conclusions: HFPG was associated with more burden in 2019. Preventive programs for diabetes and screening of individuals with diabetes for cancers, especially in older males living in developed countries, are required to arrest the large increases in HFPG-attributable cancers.

Keywords: diabetes mellitus; epidemiology; incidence; mortality; neoplasms.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Number of cancer deaths (A) and DALYs (B) attributable to high fasting plasma glucose in 2019 by cancer types and GBD region. DALY= disability-adjusted-life-years (Generated from data available from http://ghdx.healthdata.org/gbd-results-tool).
Figure 2
Figure 2
Population attributable fraction (PAF) (A) and age-standardized rates (B) of cancer deaths attributable to high fasting plasma glucose in 2019, by country. (Generated from data available from http://ghdx.healthdata.org/gbd-results-tool).
Figure 3
Figure 3
Global number of deaths and death rate (A) and global number of DALYs and DALY rate (B) of cancers attributable to high fasting plasma glucose (per 100,000) by age and sex in 2019; Dotted and dashed lines indicate 95% upper and lower uncertainty intervals, respectively. DALY= disability-adjusted-life-years. (Generated from data available from http://ghdx.healthdata.org/gbd-results-tool).
Figure 4
Figure 4
Age-standardized DALY rates of cancers attributable to high fasting plasma glucose for the 21 Global Burden of Disease regions by Socio-demographic Index, 1990–2019; Expected values based on Socio-demographic Index and disease rates in all locations are shown as the black line. Thirty points are plotted for each GBD region and show the observed age-standardized DALY rates from 1990 to 2019 for that region. DALY= disability-adjusted-life-years. (Generated from data available from http://ghdx.healthdata.org/gbd-results-tool).
See this image and copyright information in PMC

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