Subcutaneous panniculitis-like T-cell lymphoma after COVID-19 vaccination

doi:10.1016/j.jdcr.2022.08.006

Case Reports

. 2022 Oct:28:18-20.

doi: 10.1016/j.jdcr.2022.08.006. Epub 2022 Aug 10.

Subcutaneous panniculitis-like T-cell lymphoma after COVID-19 vaccination

Margaret Ann Kreher¹, John Ahn², Tyler Werbel², Kiran Motaparthi²

Affiliations

¹ University of Florida College of Medicine, Gainesville, Florida.
² Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.

PMID: 35966352
PMCID: PMC9364717
DOI: 10.1016/j.jdcr.2022.08.006

Case Reports

Subcutaneous panniculitis-like T-cell lymphoma after COVID-19 vaccination

Margaret Ann Kreher et al. JAAD Case Rep. 2022 Oct.

. 2022 Oct:28:18-20.

doi: 10.1016/j.jdcr.2022.08.006. Epub 2022 Aug 10.

Authors

Margaret Ann Kreher¹, John Ahn², Tyler Werbel², Kiran Motaparthi²

Affiliations

¹ University of Florida College of Medicine, Gainesville, Florida.
² Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.

PMID: 35966352
PMCID: PMC9364717
DOI: 10.1016/j.jdcr.2022.08.006

No abstract available

Keywords: COVID-19 vaccine; HLH, hemophagocytic lymphohistiocytosis; PET-CT, positron emission tomography–computed tomography; SPTCL; SPTCL, subcutaneous panniculitis-like T-cell lymphoma; SUV, standardized uptake value; TCR, T-cell receptor; injection site reaction; subcutaneous panniculitis-like T-cell lymphoma; viral vector vaccine.

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Conflict of interest statement

None disclosed.

Figures

**Fig 1**
Erythematous, indurated plaque on the upper arm.

**Fig 2**
Lobular panniculitis with fibrinoid necrosis (A: H&E, 150× magnification), atypical medium-sized lymphocytes rimming adipocytes, and histiocytes containing apoptotic debris (B: H&E, 400× magnification).

**Fig 3**
Resolution with atrophy following 6 weeks of combined treatment with cyclosporine and prednisone.

See this image and copyright information in PMC

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References

1. Willemze R., Jansen P.M., Cerroni L., et al. Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases. Blood. 2008;111(2):838–845. - PubMed
1. Parveen Z., Thompson K. Subcutaneous panniculitis-like T-cell lymphoma: redefinition of diagnostic criteria in the recent World Health Organization–European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas. Arch Path Lab. 2009;133(2):303–308. - PubMed
1. Willemze R., Cerroni L., Kempf W., et al. The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood. 2019;133(16):1703–1714. - PMC - PubMed
1. Abouyabis A.N., Shenoy P.J., Lechowicz M.J., Flowers C.R. Incidence and outcomes of the peripheral T-cell lymphoma subtypes in the United States. Leuk Lymphoma. 2008;49(11):2099–2107. - PubMed
1. Trainor K.J., Brisco M.J., WanNeoh J.H., Grist S., Morley A.A. Gene rearrangement in B- and T-lymphoproliferative disease detected by the polymerase chain Reaction. Blood. 1991;78:192–196. - PubMed

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[1] Willemze R., Jansen P.M., Cerroni L., et al. Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases. Blood. 2008;111(2):838–845. - PubMed

[2] Willemze R., Jansen P.M., Cerroni L., et al. Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases. Blood. 2008;111(2):838–845. - PubMed

[3] Parveen Z., Thompson K. Subcutaneous panniculitis-like T-cell lymphoma: redefinition of diagnostic criteria in the recent World Health Organization–European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas. Arch Path Lab. 2009;133(2):303–308. - PubMed

[4] Parveen Z., Thompson K. Subcutaneous panniculitis-like T-cell lymphoma: redefinition of diagnostic criteria in the recent World Health Organization–European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas. Arch Path Lab. 2009;133(2):303–308. - PubMed

[5] Willemze R., Cerroni L., Kempf W., et al. The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood. 2019;133(16):1703–1714. - PMC - PubMed

[6] Willemze R., Cerroni L., Kempf W., et al. The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood. 2019;133(16):1703–1714. - PMC - PubMed

[7] Abouyabis A.N., Shenoy P.J., Lechowicz M.J., Flowers C.R. Incidence and outcomes of the peripheral T-cell lymphoma subtypes in the United States. Leuk Lymphoma. 2008;49(11):2099–2107. - PubMed

[8] Abouyabis A.N., Shenoy P.J., Lechowicz M.J., Flowers C.R. Incidence and outcomes of the peripheral T-cell lymphoma subtypes in the United States. Leuk Lymphoma. 2008;49(11):2099–2107. - PubMed

[9] Trainor K.J., Brisco M.J., WanNeoh J.H., Grist S., Morley A.A. Gene rearrangement in B- and T-lymphoproliferative disease detected by the polymerase chain Reaction. Blood. 1991;78:192–196. - PubMed

[10] Trainor K.J., Brisco M.J., WanNeoh J.H., Grist S., Morley A.A. Gene rearrangement in B- and T-lymphoproliferative disease detected by the polymerase chain Reaction. Blood. 1991;78:192–196. - PubMed

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Subcutaneous panniculitis-like T-cell lymphoma after COVID-19 vaccination

Affiliations

Subcutaneous panniculitis-like T-cell lymphoma after COVID-19 vaccination

Authors

Affiliations

Conflict of interest statement

Figures

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References

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