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. 2022 Jul 27:13:981728.
doi: 10.3389/fpsyt.2022.981728. eCollection 2022.

Abnormal hubs in global network as neuroimaging biomarker in right temporal lobe epilepsy at rest

Ruimin Guo  1   2 , Yunfei Zhao  3 , Honghua Jin  1 , Jihua Jian  1 , Haibo Wang  4 , Shengxi Jin  3 , Hongwei Ren  1
Affiliations

Abnormal hubs in global network as neuroimaging biomarker in right temporal lobe epilepsy at rest

Ruimin Guo et al. Front Psychiatry. .

Abstract

While abnormal neuroimaging features have been reported in patients suffering from right temporal lobe epilepsy (rTLE), the value of altered degree centrality (DC) as a diagnostic biomarker for rTLE has yet to be established. As such, the present study was designed to examine DC abnormalities in rTLE patients in order to gauge the diagnostic utility of these neuroimaging features. In total, 68 patients with rTLE and 73 healthy controls (HCs) participated in this study. Imaging data were analyzed using DC and receiver operating characteristic (ROC) methods. Ultimately, rTLE patients were found to exhibit reduced right caudate DC and increased left middle temporal gyrus, superior parietal gyrus, superior frontal gyrus, right precuneus, frontal gyrus Inferior gyrus, middle-superior frontal gyrus, and inferior parietal gyrus DC relative to HC. ROC analyses indicated that DC values in the right caudate nucleus could be used to differentiate between rTLE patients and HCs with a high degree of sensitivity and specificity. Together, these results thus suggest that rTLE is associated with abnormal DC values in the right caudate nucleus, underscoring the relevance of further studies of the underlying pathophysiology of this debilitating condition.

Keywords: caudate; degree centrality; magnetic resonance imaging; receiver operating characteristic; temporal lobe epilepsy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Decreased DC values in the right caudate and increased DC values in the left middle temporal gyrus, superior parietal gyrus, superior frontal gyrus, right precuneus, frontal gyrus Inferior gyrus, middle-superior frontal gyrus, and inferior parietal gyrus in patients. DC, degree centrality; MTG, middle temporal gyrus; SPG, superior parietal gyrus; SFG, superior frontal gyrus; PCu, precuneus; IFG, frontal gyrus Inferior gyrus; MSFG, middle-superior frontal gyrus; and IPG, inferior parietal gyrus.
FIGURE 2
FIGURE 2
ROC curves for the differentiation between TLE patients and HCs based on DC values in abnormal brain regions. TLE, temporal lobe epilepsy; ROC, receiver operating characteristic; HCs, healthy controls; and DC, degree centrality.
See this image and copyright information in PMC

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