Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul 27:9:938536.
doi: 10.3389/fmed.2022.938536. eCollection 2022.

A multicenter prospective cohort study of cardiac ultrasound phenotypes in patients with sepsis: Study protocol for a multicenter prospective cohort trial

Hongxuan Zhang  1 , Xiaoting Wang  2 , Wanhong Yin  3 , Hongmin Zhang  2 , Lixia Liu  4 , Pan Pan  5 , Ying Zhu  6 , Wei Huang  7 , Zhiqun Xing  8 , Bo Yao  9 , Cui Wang  10 , Tianlai Lin  11 , Rongguo Yu  1 , Xiuling Shang  1
Affiliations

A multicenter prospective cohort study of cardiac ultrasound phenotypes in patients with sepsis: Study protocol for a multicenter prospective cohort trial

Hongxuan Zhang et al. Front Med (Lausanne). .

Abstract

Background: Sepsis-induced cardiomyopathy significantly increased the mortality of patients with sepsis. The diagnostic criteria for septic cardiomyopathy has not been unified, which brings serious difficulties to clinical treatment. This study aimed to provide evidence for the early identification and intervention in patients with sepsis by clarifying the relationship between the ultrasound phenotype of septic cardiomyopathy and the prognosis of patients with sepsis.

Methods: This was a multicenter, prospective cohort study. The study population will consist of all eligible consecutive patients with sepsis or septic shock who meet the Sepsis 3.0 diagnostic criteria and were aged ≥18 years. Clinical data and echocardiographic measurements will be recorded within 2 h, at the 24th hour, at the 72nd hour, and on the 7th day after admission. The prevalence of each phenotype will be described as well, and their association with prognosis will be analyzed statistically.

Discussion: To achieve early recognition, prevent reinjury, achieve precise treatment, and reduce mortality in patients with sepsis, it is important to identify septic cardiac alterations and classify the phenotypes at all stages of sepsis. First, there is a lack of studies on the prevalence of each phenotype in Chinese populations. Second, each phenotype and its corresponding prognosis are not clear. In addition, the prognosis of patients with normal cardiac ultrasound phenotypes vs. those with suppressed or hyperdynamic cardiac phenotypes is unclear. Finally, this study was designed to collect data at four specific timing, then the timing of occurrence, duration, changes over time, impact to outcomes of each phenotype will probably be found. This study is expected to establish a standard and objective method to assess the ultrasound phenotype of septic cardiomyopathy due to its advantages of visualization, non-invasiveness and reproducibility, and to provide more precise information for the hemodynamic management of septic patients. In addition, this research will promote the clinical application of critical care ultrasound, which will play an important role in medical education and make ultrasound the best method to assess cardiac changes in sepsis.

Trial registration: https://clinicaltrials.gov/ct2/show/NCT05161104, identifier NCT05161104.

Keywords: cardiac phenotype; prognosis; sepsis; septic cardiomyopathy; ultrasound.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Similar articles

See all similar articles

Cited by

References

    1. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. . The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. (2016) 315:801–10. 10.1001/jama.2016.0287 - DOI - PMC - PubMed
    1. Havaldar AA. Evaluation of sepsis induced cardiac dysfunction as a predictor of mortality. Cardiovasc Ultrasound. (2018) 16:31. 10.1186/s12947-018-0149-4 - DOI - PMC - PubMed
    1. Wang J, Wang XT, Liu DW, Zhang HM. Su LX.Induction and deduction in sepsis-induced cardiomyopathy: five typical categories. Chin. Med. J. (2020) 133:2205–11. 10.1097/CM9.0000000000000929 - DOI - PMC - PubMed
    1. Beesley SJ, Weber G, Sarge T, Nikravan S, Grissom CK, Lanspa MJ, et al. . Septic Cardiomyopathy. Crit Care Med. (2018) 46:625–34. 10.1097/CCM.0000000000002851 - DOI - PubMed
    1. Liu V, Escobar GJ, Greene JD, Soule J, Whippy A, Angus DC, et al. . Hospital deaths in patients with sepsis from 2 independent cohorts. JAMA. (2014) 312:90–2. 10.1001/jama.2014.5804 - DOI - PubMed

Associated data