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Case Reports
. 2022 May 3;7(8):1913-1916.
doi: 10.1016/j.ekir.2022.04.089. eCollection 2022 Aug.

Atypical Antiglomerular Basement Membrane Nephritis Following Immune Checkpoint Inhibitor

Vincent Javaugue  1   2 , Myra J Watson  3 , Fernando C Fervenza  1 , Samih H Nasr  4
Affiliations
Case Reports

Atypical Antiglomerular Basement Membrane Nephritis Following Immune Checkpoint Inhibitor

Vincent Javaugue et al. Kidney Int Rep. .
No abstract available

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Figures

Figure 1
Figure 1
Kidney biopsy findings. (a) The glomerulus exhibits endocapillary hypercellularity with abundant intracapillary infiltrating neutrophils and monocytes, mesangial sclerosis and hypercellularity, thickening of the GBM, and a tiny cellular crescent (arrow) (periodic acid-Schiff, ×400). An adjacent arteriole has intimal hyalinosis. (b) Another glomerulus reveals nodular mesangial sclerosis and a fibrocellular crescent associated with fibrinoid necrosis (small arrow) and rupture of Bowman’s capsule (long arrow) (trichrome stain, ×200). (c) There is bright, linear staining of the GBM and few tubular basement membranes (arrow) for IgG (immunofluorescent image, ×200). (d) There is bright, linear GBM staining for IgG2 (immunofluorescent image, ×400). The glomeruli were negative for IgG1, IgG3, and IgG4 (not illustrated). GBM, glomerular basement membrane.
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References

    1. Jennette J.C. Rapidly progressive crescentic glomerulonephritis. Kidney Int. 2003;63:1164–1177. doi: 10.1046/j.1523-1755.2003.00843.x. - DOI - PubMed
    1. Nasr S.H., Collins A.B., Alexander M.P., et al. The clinicopathologic characteristics and outcome of atypical anti-glomerular basement membrane nephritis. Kidney Int. 2016;89:897–908. doi: 10.1016/j.kint.2016.02.001. - DOI - PubMed
    1. Brahmer J.R., Lacchetti C., Schneider B.J., et al. Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2018;36:1714–1768. doi: 10.1200/JCO.2017.77.6385. - DOI - PMC - PubMed
    1. Kitchlu A., Jhaveri K.D., Wadhwani S., et al. A systematic review of immune checkpoint inhibitor-associated glomerular disease. Kidney Int Rep. 2021;6:66–77. doi: 10.1016/j.ekir.2020.10.002. - DOI - PMC - PubMed
    1. Gupta S., Cortazar F.B., Riella L.V., Leaf D.E. Immune checkpoint inhibitor nephrotoxicity: update 2020. Kidney360. 2020;1:130–140. doi: 10.34067/KID.0000852019. - DOI - PMC - PubMed

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