GSTM1 Copy Number and Kidney Disease in People With HIV

Rachel K Y Hung¹, Kerry-Lee Rosenberg², Victor David³, Elizabeth Binns-Roemer³, John W Booth⁴, Rachel Hilton⁵, Julie Fox^{1

5}, Fiona Burns², Andrew Ustianowski⁶, Catherine Cosgrove⁷, Lisa Hamzah⁷, James E Burns^{8

9}, Amanda Clarke^{10

11}, David Chadwick¹², David A Price¹³, Stephen Kegg¹⁴, Lucy Campbell¹, Kate Bramham^{1

15}, Caroline A Sabin⁸, Frank A Post^{1

15}, Cheryl A Winkler²; GEN-AFRICA Study Group

Collaborators, Affiliations

Collaborators

GEN-AFRICA Study Group:
Anele Waters, James Hand, Chris Clarke, Sarah Murphy, Maurice Murphy, Marion Campbell, Celia Richardson, Alyson Knott, Gemma Weir, Rebecca Cleig, Helena Soviarova, Lisa Barbour, Tanya Adams, Vicky Kennard, Vittorio Trevitt, Rachael Jones, Jeremy Levy, Alexandra Schoolmeester, Serah Duro, May Rabuya, Deborah Jordan, Teresa Solano, Hiromi Uzu, Karen Williams, Julianne Lwanga, Linda Ekaette Reid-Amoruso, Hannah Gamlen, Robert J Stocker, Fiona Ryan, Anele Waters, Karina Mahiouz, Tess Cheetham, Claire Williams, Achyuta Nori, Caroline Thomas, Sivaraj Venkateshwaran, Jessica Doctor, Andrea Berlanga, Beatriz Santana-Suarez, Leigh McQueen, Priya Bhagwandin, Bee Barbini, Emily Wandolo, Tim Appleby, Deborah Jordan, Lois Driver, Sophy Parr, Hongbo Deng, Julie Barber, Andrew Crowe, Chris Taylor, Mary Poulton, Vida Boateng, Marie-Pierre Klein, Caitlin O'Brien, Samuel Ohene-Adomako, Christian Buckingham, Daniel Trotman, Killian Quinn, Kate Flanagan, Verity Sullivan, Holly Middleditch, Itty Samuel, Elizabeth Hamlyn, Candice McDonald, Ana Canoso, Emeka Agbasi, Maria Liskova, Sarah Barber, Amanda Samarawickrama, Zoe Ottaway, Claire Norcross, Amelia Oliveira, Jane Minton, Gary Lamont, Ruby Cross, Gaushiya Saiyad, Shadia Ahmed, Rebecca Ashworth, Nicola Window, J Murira, Khine Phyu, Gabriella Lindergard, Jonathan Shaw, Sarah Holland, Claire Fox, Jan Flaherty, Margaret-Anne Bevan, Valerie George, Marie Branch, Pauline Lambert, Adele Craggs, Sarah Pett, Hinal Lukha, Nina Vora, Marzia Fiorino, Maria Muller Nunez, Deirdre Sally, Erica Pool, Rebecca Matthews, Tara Stothard, Bijal Patel, Ian McVittie, Ciara Kennedy, Uli Shwab, Brendan Payne, Sarah Duncan, Jill Dixon, Mathias Schmid, Adam Evans, Christopher Duncan, Ewan Hunter, Yusri Taha, Natasha Astill, Jonathan Ainsworth, Rachel Vincent, Chloe Saad, Sarah Skinner, Hocine Azzoug, Judith Russell, Tarik Moussaoui, Celia Richardson, Emily Mabonga, Donna Ward, J Francoise, W Larbi, Sue Mitchell, A Manning, V Russell, Mark Harber, Nnenna Ngwu, Jonathan Edwards, Nargis Hemat, Tom Fernandez, Filippo Ferro, Jorge Ferreira, Alice Nightingale, Tasha Oakes-Monger, Darwin Matila, Pedro Nogueira, Victoria Mutagwanya, Catherine Emily Isitt, Helen Webb, Joyce Popoola, Kate Korley, Mark Mencias, Patricia Ribeiro, Rajeshwar Ramkhelawn, Sandra Oliva Lara, Sara Sajijad, Alan Winston, Jeremy Levy, Amber Shaw, Claire Petersen, Kyle Ring, Melanie Rosenvinge, Chloe Saad, Sarah Skinner, Thembi Moyo, Faith Odong, Katherine Gantert, Tina Ibe, Denis Onyango, Teresa Hill

Affiliations

¹ King's College London, London, UK.
² Royal Free London Hospital NHS Foundation Trust, London, UK.
³ Basic Research Laboratory, Frederick National Laboratory for Cancer Research and the National Cancer Institute, Frederick, USA.
⁴ Barts Health NHS Trust, London, UK.
⁵ Guy's and St Thomas' NHS Foundation Trust, London, UK.
⁶ Pennine Acute Hospitals NHS Foundation Trust, Manchester, UK.
⁷ St George's Hospital NHS Foundation Trust, London, UK.
⁸ University College London, London, UK.
⁹ Central and North West London NHS Foundation Trust, London, UK.
¹⁰ Brighton and Sussex University Hospital NHS Trust, Brighton, UK.
¹¹ Brighton and Sussex Medical School Department of Infectious Disease, Brighton, UK.
¹² South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.
¹³ The Newcastle Upon Tyne Hospitals, Newcastle, UK.
¹⁴ Lewisham and Greenwich NHS Trust, London, UK.
¹⁵ King's College Hospital NHS Foundation Trust, London, UK.

PMID: 35967115
PMCID: PMC9366293
DOI: 10.1016/j.ekir.2022.05.003

GSTM1 Copy Number and Kidney Disease in People With HIV

Rachel K Y Hung et al. Kidney Int Rep. 2022.

. 2022 May 13;7(8):1901-1904.

doi: 10.1016/j.ekir.2022.05.003. eCollection 2022 Aug.

Authors

Collaborators

GEN-AFRICA Study Group:
Anele Waters, James Hand, Chris Clarke, Sarah Murphy, Maurice Murphy, Marion Campbell, Celia Richardson, Alyson Knott, Gemma Weir, Rebecca Cleig, Helena Soviarova, Lisa Barbour, Tanya Adams, Vicky Kennard, Vittorio Trevitt, Rachael Jones, Jeremy Levy, Alexandra Schoolmeester, Serah Duro, May Rabuya, Deborah Jordan, Teresa Solano, Hiromi Uzu, Karen Williams, Julianne Lwanga, Linda Ekaette Reid-Amoruso, Hannah Gamlen, Robert J Stocker, Fiona Ryan, Anele Waters, Karina Mahiouz, Tess Cheetham, Claire Williams, Achyuta Nori, Caroline Thomas, Sivaraj Venkateshwaran, Jessica Doctor, Andrea Berlanga, Beatriz Santana-Suarez, Leigh McQueen, Priya Bhagwandin, Bee Barbini, Emily Wandolo, Tim Appleby, Deborah Jordan, Lois Driver, Sophy Parr, Hongbo Deng, Julie Barber, Andrew Crowe, Chris Taylor, Mary Poulton, Vida Boateng, Marie-Pierre Klein, Caitlin O'Brien, Samuel Ohene-Adomako, Christian Buckingham, Daniel Trotman, Killian Quinn, Kate Flanagan, Verity Sullivan, Holly Middleditch, Itty Samuel, Elizabeth Hamlyn, Candice McDonald, Ana Canoso, Emeka Agbasi, Maria Liskova, Sarah Barber, Amanda Samarawickrama, Zoe Ottaway, Claire Norcross, Amelia Oliveira, Jane Minton, Gary Lamont, Ruby Cross, Gaushiya Saiyad, Shadia Ahmed, Rebecca Ashworth, Nicola Window, J Murira, Khine Phyu, Gabriella Lindergard, Jonathan Shaw, Sarah Holland, Claire Fox, Jan Flaherty, Margaret-Anne Bevan, Valerie George, Marie Branch, Pauline Lambert, Adele Craggs, Sarah Pett, Hinal Lukha, Nina Vora, Marzia Fiorino, Maria Muller Nunez, Deirdre Sally, Erica Pool, Rebecca Matthews, Tara Stothard, Bijal Patel, Ian McVittie, Ciara Kennedy, Uli Shwab, Brendan Payne, Sarah Duncan, Jill Dixon, Mathias Schmid, Adam Evans, Christopher Duncan, Ewan Hunter, Yusri Taha, Natasha Astill, Jonathan Ainsworth, Rachel Vincent, Chloe Saad, Sarah Skinner, Hocine Azzoug, Judith Russell, Tarik Moussaoui, Celia Richardson, Emily Mabonga, Donna Ward, J Francoise, W Larbi, Sue Mitchell, A Manning, V Russell, Mark Harber, Nnenna Ngwu, Jonathan Edwards, Nargis Hemat, Tom Fernandez, Filippo Ferro, Jorge Ferreira, Alice Nightingale, Tasha Oakes-Monger, Darwin Matila, Pedro Nogueira, Victoria Mutagwanya, Catherine Emily Isitt, Helen Webb, Joyce Popoola, Kate Korley, Mark Mencias, Patricia Ribeiro, Rajeshwar Ramkhelawn, Sandra Oliva Lara, Sara Sajijad, Alan Winston, Jeremy Levy, Amber Shaw, Claire Petersen, Kyle Ring, Melanie Rosenvinge, Chloe Saad, Sarah Skinner, Thembi Moyo, Faith Odong, Katherine Gantert, Tina Ibe, Denis Onyango, Teresa Hill

Affiliations

¹ King's College London, London, UK.
² Royal Free London Hospital NHS Foundation Trust, London, UK.
³ Basic Research Laboratory, Frederick National Laboratory for Cancer Research and the National Cancer Institute, Frederick, USA.
⁴ Barts Health NHS Trust, London, UK.
⁵ Guy's and St Thomas' NHS Foundation Trust, London, UK.
⁶ Pennine Acute Hospitals NHS Foundation Trust, Manchester, UK.
⁷ St George's Hospital NHS Foundation Trust, London, UK.
⁸ University College London, London, UK.
⁹ Central and North West London NHS Foundation Trust, London, UK.
¹⁰ Brighton and Sussex University Hospital NHS Trust, Brighton, UK.
¹¹ Brighton and Sussex Medical School Department of Infectious Disease, Brighton, UK.
¹² South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.
¹³ The Newcastle Upon Tyne Hospitals, Newcastle, UK.
¹⁴ Lewisham and Greenwich NHS Trust, London, UK.
¹⁵ King's College Hospital NHS Foundation Trust, London, UK.

PMID: 35967115
PMCID: PMC9366293
DOI: 10.1016/j.ekir.2022.05.003

No abstract available

Keywords: APOL1; Africa; GSTM1; HIV; kidney; oxidative stress.

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Figures

**Figure 1**
Distribution of eGFR in participants stratified by *GSTM1* genotype, overall (a) and in those with *APOL1* low-risk (b) and high-risk (c) genotypes.

See this image and copyright information in PMC

References

1. Duni A., Liakopoulos V., Roumeliotis S., et al. Oxidative stress in the pathogenesis and evolution of chronic kidney disease: untangling Ariadne’s thread. Int J Mol Sci. 2019;20 doi: 10.3390/ijms20153711. - DOI - PMC - PubMed
1. Bodonyi-Kovacs G., Ma J.Z., Chang J., et al. Combined effects of GSTM1 null allele and APOL1 renal risk alleles in CKD progression in the African American study of kidney disease and hypertension trial. J Am Soc Nephrol. 2016;27:3140–3152. doi: 10.1681/ASN.2015050487. - DOI - PMC - PubMed
1. Chang J., Ma J.Z., Zeng Q., et al. Loss of GSTM1, a NRF2 target, is associated with accelerated progression of hypertensive kidney disease in the African American Study of Kidney Disease (AASK) Am J Physiol Ren Physiol. 2013;304:F348–F355. doi: 10.1152/ajprenal.00568.2012. - DOI - PMC - PubMed
1. Tin A., Scharpf R., Estrella M.M., et al. The loss of GSTM1 associates with kidney failure and heart failure. J Am Soc Nephrol. 2017;28:3345–3352. doi: 10.1681/ASN.2017030228. - DOI - PMC - PubMed
1. Hung R.K.Y., Santana-Suarez B., Binns-Roemer E., et al. The epidemiology of kidney disease in people of African ancestry with HIV in the UK. EClinicalMedicine. 2021;38:101006. doi: 10.1016/j.eclinm.2021.101006. - DOI - PMC - PubMed

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GSTM1 Copy Number and Kidney Disease in People With HIV

Collaborators

Affiliations

GSTM1 Copy Number and Kidney Disease in People With HIV

Authors

Collaborators

Affiliations

Figures

References

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Research Materials

Miscellaneous