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Review
. 2022 Jul 11;14(7):e26751.
doi: 10.7759/cureus.26751. eCollection 2022 Jul.

The Role of Leptin in Systemic Lupus Erythematosus: Is It Still a Mystery?

Nicole Villa  1 , Omar Badla  2 , Raman Goit  1 , Samia E Saddik  1 , Sarah N Dawood  3 , Ahmad M Rabih  1 , Ahmad Mohammed  1 , Aishwarya Raman  1 , Manish Uprety  1 , Maria Jose Calero  4 , Maria Resah B Villanueva  5 , Narges Joshaghani  6 , Lubna Mohammed  1
Affiliations
Review

The Role of Leptin in Systemic Lupus Erythematosus: Is It Still a Mystery?

Nicole Villa et al. Cureus. .

Abstract

Systemic lupus erythematosus (SLE) is a chronic inflammatory connective tissue disease with varying clinical manifestations. Recent studies have proposed that leptin may be related to SLE development. This study aims to assess current information regarding the relationship between leptin and SLE. A systematic search was done using PubMed, Google Scholar, ScienceDirect, Epistemonikos, and Cochrane Library databases. Studies published in the English language in the last 10 years were selected based on predefined eligibility criteria. The quality of the studies was evaluated using the Newcastle-Ottawa Scale and the Assessment of Multiple Systematic Reviews 2 tool. A total of 12 studies were included in this systematic review. These included systematic reviews/meta-analyses, cross-sectional studies, and case-control studies. Based on the findings of this review, we conclude thatleptin is significantly elevated in SLE patients; however, it does not seem to correlate with disease activity. The exact mechanism of leptin in the pathogenesis of the disease remains unknown and further research is needed regarding this aspect.

Keywords: leptin; leptin receptor; sle; systematic review; systemic lupus erythematosus.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. PRISMA flowchart of the study search selection.
PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses
See this image and copyright information in PMC

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