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Review
. 2022 Jul 25:10:945175.
doi: 10.3389/fped.2022.945175. eCollection 2022.

The role of necroptosis in common respiratory diseases in children

Junjie Ning  1   2   3 , Lina Qiao  1   2   3
Affiliations
Review

The role of necroptosis in common respiratory diseases in children

Junjie Ning et al. Front Pediatr. .

Abstract

Studies have shown that necroptosis (NEC) relies on a unique gene-regulated molecular pathway to cause cell death. With the development of knockout mouse models and specific molecular inhibitors of necrotic proteins, this cell death pathway has been considered one of the important causes of the pathogenesis of human diseases. In this review, we explored the possible roles and mechanisms of NEC in common respiratory diseases in children, such as acute lung injury, acute respiratory distress syndrome, pulmonary infection, childhood asthma, pulmonary hypertension, etc., in order to provide new ideas for the prevention and treatment of such diseases.

Keywords: MLKL; Necrostatin-1; RIPK1; RIPK3; necroptosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Schematic diagram of the molecular mechanism of TNF-α-mediated NEC.
See this image and copyright information in PMC

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