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. 2022 Jul 26:10:915943.
doi: 10.3389/fped.2022.915943. eCollection 2022.

Vitamin D Status Among Children With Juvenile Idiopathic Arthritis: A Multicenter Prospective, Non-randomized, Comparative Study

Elena I Kondratyeva  1   2 , Nuriniso D Odinaeva  2 , Leonid Ya Klimov  3 , Nadeshda S Podchernyaeva  4 , Natalya I Ilenkova  5 , Svetlana V Dolbnya  3 , Elena K Zhekaite  1   2 , Victoria A Kuryaninova  3 , Yuliya V Kotova  2 , Margarita I Tikhaya  4 , Elena P Shitkovskaya  5 , Liubov V Bychina  5 , Tamara G Drepa  3 , Aisa E Zodbinova  1 , Yuliya L Melyanovskaya  1   2 , Nika V Petrova  1 , Elena V Loshkova  2 , Sergei I Kutsev  1
Affiliations

Vitamin D Status Among Children With Juvenile Idiopathic Arthritis: A Multicenter Prospective, Non-randomized, Comparative Study

Elena I Kondratyeva et al. Front Pediatr. .

Abstract

Background: Juvenile idiopathic arthritis (JIA) is a chronic autoimmune disease characterized by destructive and inflammatory damage to the joints. The aim in this study was to compare vitamin D levels between children and adolescents, 1-18 years of age, with juvenile idiopathic arthritis (JIA) and a health control group of peers. We considered effects of endogenous, exogenous, and genetic factors on measured differences in vitamin D levels among children with JIA.

Methods: Our findings are based on a study sample of 150 patients with various variants of JIA and 277 healthy children. The blood level of vitamin D was assessed by calcidiol level. The following factors were included in our analysis: age and sex; level of insolation in three regions of country (center, south, north); assessment of dietary intake of vitamin D; effect of prophylactic doses of cholecalciferol; a relationship between the TaqI, FokI, and BsmI polymorphisms of the VDR gene and serum 25(OH)D concentration.

Results: We identified a high frequency of low vitamin D among children with JIA, prevalence of 66%, with the medial level of vitamin D being within the range of "insufficient" vitamin D. We also show that the dietary intake of vitamin D by children with JIA is well below expected norms, and that prophylactic doses of vitamin D supplementation (cholecalciferol) at a dose of 500-1,000 IU/day and 1,500-2,000 IU/day do not meet the vitamin D needs of children with JIA. Of importance, we show that vitamin D levels among children with JIA are not affected by clinical therapies to manage the disease nor by the present of VDR genetic variants.

Conclusion: Prophylactic administration of cholecalciferol and season of year play a determining role in the development of vitamin D deficiency and insufficiency.

Keywords: VDR gene; genotypes; juvenile idiopathic arthritis; seasons of the year; vitamin D deficiency.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict ofinterest.

Figures

Figure 1
Figure 1
Comparison of the level of vitamin D (serum calcidiol, ng/mL) between the JIA and control group by geographical region included in the analysis.
Figure 2
Figure 2
Calcidiol (25(OH)D) level (ng/mL) for the JIA and control groups for each season.
Figure 3
Figure 3
Comparison of the distribution of vitamin D status among the JIA and control groups for each season.
Figure 4
Figure 4
Distribution of vitamin D status as a function of the dose of cholecalciferol supplementation.*p < 0.001, comparison between the JIA and control group, calculated using Pearson's χ2. **p < 0.05, comparison between the JIA and control group, calculated using Fisher's exact test.
See this image and copyright information in PMC

References

    1. Martini A, Ravelli A, Avcin T, Beresford MW, Burgos-Vargas R, Cuttica R, et al. Pediatric Rheumatology International Trials Organization (PRINTO). Toward new classification criteria for Juvenile Idiopathic Arthritis: First steps, Pediatric Rheumatology International Trials Organization International Consensus. J Rheumatol. (2019) 46:190–7. 10.3899/jrheum.180168 - DOI - PubMed
    1. Alekseeva EI, Anan'eva LP, Baranov AA, Dvoryakovskaya TM, Valieva SI, Denisova RV, et al. Rheumatic diseases in children. In: Baranova AA, Alekseeva EI, editors. Clinical Guidelines for Pediatricians. Moscow: Publ. Pediatr. (2016). p. 144. (In Russian).
    1. Manners PJ, Bower C. Worldwide prevalence of juvenile arthritis why does it vary so much? J Rheumatol. (2002) 29:1520–30. - PubMed
    1. Weiss JE, Ilowite NT. Juvenile idiopathic arthritis. Pediatr Clin North Am. (2005) 52:413–42. 10.1016/j.pcl.2005.01.007 - DOI - PubMed
    1. Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiol Rev. (2016) 96:365–408. 10.1152/physrev.00014.2015 - DOI - PMC - PubMed

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