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Review
. 2022 Jul 28:10:954735.
doi: 10.3389/fped.2022.954735. eCollection 2022.

Current therapy option for necrotizing enterocolitis: Practicalities and challenge

Huihuan Wu  1   2 , Kehang Guo  1   2 , Zewei Zhuo  1   3 , Ruijie Zeng  1   4 , Yujun Luo  1 , Qi Yang  1 , Jingwei Li  1 , Rui Jiang  1   2 , Zena Huang  5 , Weihong Sha  1   2 , Hao Chen  1   2
Affiliations
Review

Current therapy option for necrotizing enterocolitis: Practicalities and challenge

Huihuan Wu et al. Front Pediatr. .

Abstract

Necrotizing enterocolitis (NEC) is one of the most prevalent neonatal gastrointestinal disorders. Despite ongoing breakthroughs in its treatment and prevention, the incidence and mortality associated with NEC remain high. New therapeutic approaches, such as breast milk composition administration, stem cell therapy, immunotherapy, and fecal microbiota transplantation (FMT) have recently evolved the prevention and the treatment of NEC. This study investigated the most recent advances in NEC therapeutic approaches and discussed their applicability to bring new insight to NEC treatment.

Keywords: breast milk composition; fecal microbiota transplantation; immunotherapy; necrotizing enterocolitis; stem cell.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The mechanisms of NEC. It is thought that NEC has complex and multiple mechanisms.
FIGURE 2
FIGURE 2
Research progress in necrotizing enterocolitis treatment. Effective treatments for NEC include breast milk composition administration, stem cell therapy, fecal microbiota transplantation (FMT) and immunotherapy.
FIGURE 3
FIGURE 3
Stem cells and exosomes have been used in the therapy of experimental NECs. Umbilical cord, embryonic, bone marrow, amniotic fluid and so on, have the ability to create stem cells, and all stem cells have the able to generate exosomes, which both can all be treated to treat NEC.
See this image and copyright information in PMC

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