Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jul 28:10:954735.
doi: 10.3389/fped.2022.954735. eCollection 2022.

Current therapy option for necrotizing enterocolitis: Practicalities and challenge

Huihuan Wu  1   2 , Kehang Guo  1   2 , Zewei Zhuo  1   3 , Ruijie Zeng  1   4 , Yujun Luo  1 , Qi Yang  1 , Jingwei Li  1 , Rui Jiang  1   2 , Zena Huang  5 , Weihong Sha  1   2 , Hao Chen  1   2
Affiliations
Review

Current therapy option for necrotizing enterocolitis: Practicalities and challenge

Huihuan Wu et al. Front Pediatr. .

Abstract

Necrotizing enterocolitis (NEC) is one of the most prevalent neonatal gastrointestinal disorders. Despite ongoing breakthroughs in its treatment and prevention, the incidence and mortality associated with NEC remain high. New therapeutic approaches, such as breast milk composition administration, stem cell therapy, immunotherapy, and fecal microbiota transplantation (FMT) have recently evolved the prevention and the treatment of NEC. This study investigated the most recent advances in NEC therapeutic approaches and discussed their applicability to bring new insight to NEC treatment.

Keywords: breast milk composition; fecal microbiota transplantation; immunotherapy; necrotizing enterocolitis; stem cell.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The mechanisms of NEC. It is thought that NEC has complex and multiple mechanisms.
FIGURE 2
FIGURE 2
Research progress in necrotizing enterocolitis treatment. Effective treatments for NEC include breast milk composition administration, stem cell therapy, fecal microbiota transplantation (FMT) and immunotherapy.
FIGURE 3
FIGURE 3
Stem cells and exosomes have been used in the therapy of experimental NECs. Umbilical cord, embryonic, bone marrow, amniotic fluid and so on, have the ability to create stem cells, and all stem cells have the able to generate exosomes, which both can all be treated to treat NEC.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nino DF, Sodhi CP, Hackam DJ. Necrotizing enterocolitis: new insights into pathogenesis and mechanisms. Nat Rev Gastroenterol Hepatol. (2016) 13:590–600. - PMC - PubMed
    1. Thyoka M, de Coppi P, Eaton S, Khoo K, Hall NJ, Curry J, et al. Advanced necrotizing enterocolitis part 1: mortality. Eur J Pediatr Surg. (2012) 22:8–12. - PubMed
    1. Spencer AU, Kovacevich D, McKinney-Barnett M, Hair D, Canham J, Maksym C, et al. Pediatric short-bowel syndrome: the cost of comprehensive care. Am J Clin Nutr. (2008) 88:1552–9. - PubMed
    1. Bazacliu C, Neu J. Necrotizing enterocolitis: long term complications. Curr Pediatr Rev. (2019) 15:115–24. - PubMed
    1. Weintraub AS, Ferrara L, Deluca L, Moshier E, Green RS, Oakman E, et al. Antenatal antibiotic exposure in preterm infants with necrotizing enterocolitis. J Perinatol. (2012) 32:705–9. - PubMed

LinkOut - more resources