Modeling liver hereditary hemorrhagic telangiectasia with right heart overload to the core of liver sinusoidal endothelial cells

Affiliations

Free article

Editorial

Orlando Musso. Hepatology. 2023.

Free article

. 2023 Apr 1;77(4):1081-1084.

doi: 10.1002/hep.32729. Epub 2022 Sep 12.

¹ INSERM, INRAE , Univ Rennes , Nutrition Metabolism and Cancer , Rennes , France.

No abstract available

Comment on

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver.
Schmid CD, Olsavszky V, Reinhart M, Weyer V, Trogisch FA, Sticht C, Winkler M, Kürschner SW, Hoffmann J, Ola R, Staniczek T, Heineke J, Straub BK, Mittler J, Schledzewski K, Ten Dijke P, Richter K, Dooley S, Géraud C, Goerdt S, Koch PS. Schmid CD, et al. Hepatology. 2023 Apr 1;77(4):1211-1227. doi: 10.1002/hep.32641. Epub 2022 Jul 17. Hepatology. 2023. PMID: 35776660 Free PMC article.

1. McDonald J, Stevenson DA. Hereditary hemorrhagic telangiectasia. In: Adam MP, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, , editors. GeneReviews. Seattle, WA: University of Washington; 1993–2022. p. 1–26.
1. Snodgrass RO, Chico TJA, Arthur HM. Hereditary haemorrhagic telangiectasia, an inherited vascular disorder in need of improved evidence‐based pharmaceutical interventions. Genes (Basel). 2021;12:174.
1. Medina‐Jover F, Riera‐Mestre A, Vinals F. Rethinking growth factors: the case of BMP9 during vessel maturation. Vasc Biol. 2022;4:R1–14.
1. Garcia de Vinuesa A, Abdelilah‐Seyfried S, Knaus P, Zwijsen A, Bailly S. BMP signaling in vascular biology and dysfunction. Cytokine Growth Factor Rev. 2016;27:65–79.
1. Demagny H, Araki T, De Robertis EM. The tumor suppressor Smad4/DPC4 is regulated by phosphorylations that integrate FGF, Wnt, and TGF‐beta signaling. Cell Rep. 2014;9:688–700.