Natural selfish genetic elements should not be defined as gene drives

Affiliations

Comment

Mark A Wells et al. Proc Natl Acad Sci U S A. 2022.

. 2022 Aug 23;119(34):e2201142119.

doi: 10.1073/pnas.2201142119. Epub 2022 Aug 15.

No abstract available

Conflict of interest statement

The authors declare no competing interest.

Opinion: Standardizing the definition of gene drive.
Alphey LS, Crisanti A, Randazzo FF, Akbari OS. Alphey LS, et al. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):30864-30867. doi: 10.1073/pnas.2020417117. Epub 2020 Nov 18. Proc Natl Acad Sci U S A. 2020. PMID: 33208534 Free PMC article. No abstract available.

1. Alphey L. S., Crisanti A., Randazzo F. F., Akbari O. S., Standardizing the definition of gene drive. Proc. Natl. Acad. Sci. U.S.A. 117, 30864–30867 (2020). - PMC - PubMed
1. Simon S., Otto M., Engelhard M., Synthetic gene drive: Between continuity and novelty: Crucial differences between gene drive and genetically modified organisms require an adapted risk assessment for their use. EMBO Rep. 19, e45760 (2018). - PMC - PubMed
1. Dolezel M., Samson S., Otto M., Engelhard M., Zughart W., “Gene drive organisms: Implications for the environment and nature conservation” (Umweltbundesamt - Environment Agency Austria, 2019).
1. Redford K. H., Brooks T. M., Macfarlane N. B. W., Adams J. S., “Genetic frontiers for conservation: An assessment of synthetic biology and biodiversity conservation: Technical assessment” (International Union for Conservation of Nature, 2019).
1. Kyrou K., et al. , A CRISPR-Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes. Nat. Biotechnol. 36, 1062–1066 (2018). - PMC - PubMed