Relapse and Remission in Children With Chronic Noninfectious Uveitis Treated With Methotrexate

doi:10.3899/jrheum.220007

. 2022 Nov;49(11):1289-1291.

doi: 10.3899/jrheum.220007. Epub 2022 Aug 15.

Relapse and Remission in Children With Chronic Noninfectious Uveitis Treated With Methotrexate

Affiliations

¹ Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
² Francis I. Proctor Foundation for Research in Ophthalmology, and Department of Ophthalmology University of California, San Francisco, San Francisco, California.
³ Department of Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska.
⁴ Children's Healthcare of Atlanta, Atlanta, Georgia.
⁵ Department of Ophthalmology, Stanford University, Stanford, California.
⁶ Department of Genetics, Emory University School of Medicine, Atlanta, Georgia.
⁷ Department of Global and Community Health, George Mason University, Fairfax, Virginia.
⁸ Division of Rheumatology and Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA. sheila.angeles-han@cchmc.org.

PMID: 35970521
PMCID: PMC10151125
DOI: 10.3899/jrheum.220007

Relapse and Remission in Children With Chronic Noninfectious Uveitis Treated With Methotrexate

Courtney McCracken et al. J Rheumatol. 2022 Nov.

. 2022 Nov;49(11):1289-1291.

doi: 10.3899/jrheum.220007. Epub 2022 Aug 15.

Authors

Affiliations

¹ Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
² Francis I. Proctor Foundation for Research in Ophthalmology, and Department of Ophthalmology University of California, San Francisco, San Francisco, California.
³ Department of Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska.
⁴ Children's Healthcare of Atlanta, Atlanta, Georgia.
⁵ Department of Ophthalmology, Stanford University, Stanford, California.
⁶ Department of Genetics, Emory University School of Medicine, Atlanta, Georgia.
⁷ Department of Global and Community Health, George Mason University, Fairfax, Virginia.
⁸ Division of Rheumatology and Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA. sheila.angeles-han@cchmc.org.

PMID: 35970521
PMCID: PMC10151125
DOI: 10.3899/jrheum.220007

No abstract available

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Conflict of interest statement

SY is a consultant for Santen and Clearside Biomedical, unrelated to this study. KARS is a consultant for Accordant, unrelated to this study. SP serves on the Macrophage Activation Syndrome Adjudication Committee for Novartis and is a Doximity Op-Med Fellow for 2021–22, unrelated to this study. The remaining authors declare no conflicts of interest relevant to this article.

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Cited by

Diagnosis and Treatment of Uveitis in Children: A Summary of the Latest Data from a 5-Year Literature Review (2018-2023).
Modrzejewska M, Zdanowska O. Modrzejewska M, et al. J Clin Med. 2024 May 25;13(11):3097. doi: 10.3390/jcm13113097. J Clin Med. 2024. PMID: 38892808 Free PMC article. Review.
Effects of methotrexate combined with tocilizumab on growth and bone metabolism in children with juvenile idiopathic arthritis.
Yang H, Lan C, Xie J, Xun C, Wang M, Rong K, Kuang J. Yang H, et al. Am J Transl Res. 2023 May 15;15(5):3530-3538. eCollection 2023. Am J Transl Res. 2023. PMID: 37303692 Free PMC article.

References

1. Lerman MA, Lewen MD, Kempen JH, Mills MD. Uveitis reactivation in children treated with tumor necrosis factor alpha inhibitors. Am J Ophthalmol 2015;160:193–200. - PMC - PubMed
1. Simonini G, Bracaglia C, Cattalini M, et al. Predictors of relapse after discontinuing systemic treatment in childhood autoimmune chronic uveitis. J Rheumatol 2017;44:822–6. - PubMed
1. Kalinina Ayuso V, van de Winkel EL, Rothova A, de Boer JH. Relapse rate of uveitis post-methotrexate treatment in juvenile idiopathic arthritis. Am J Ophthalmol 2011;151:217–22. - PubMed
1. Saboo US, Metzinger JL, Radwan A, et al. Risk factors associated with the relapse of uveitis in patients with juvenile idiopathic arthritis: a preliminary report. J AAPOS 2013;17:460–4. - PubMed
1. Acharya NR, Ebert CD, Kelly NK, et al. Discontinuing adalimumab in patients with controlled juvenile idiopathic arthritis-associated uveitis (ADJUST-Adalimumab in Juvenile Idiopathic Arthritis-associated Uveitis Stopping Trial): study protocol for a randomised controlled trial. Trials 2020;21:887. - PMC - PubMed

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[1] Lerman MA, Lewen MD, Kempen JH, Mills MD. Uveitis reactivation in children treated with tumor necrosis factor alpha inhibitors. Am J Ophthalmol 2015;160:193–200. - PMC - PubMed

[2] Lerman MA, Lewen MD, Kempen JH, Mills MD. Uveitis reactivation in children treated with tumor necrosis factor alpha inhibitors. Am J Ophthalmol 2015;160:193–200. - PMC - PubMed

[3] Simonini G, Bracaglia C, Cattalini M, et al. Predictors of relapse after discontinuing systemic treatment in childhood autoimmune chronic uveitis. J Rheumatol 2017;44:822–6. - PubMed

[4] Simonini G, Bracaglia C, Cattalini M, et al. Predictors of relapse after discontinuing systemic treatment in childhood autoimmune chronic uveitis. J Rheumatol 2017;44:822–6. - PubMed

[5] Kalinina Ayuso V, van de Winkel EL, Rothova A, de Boer JH. Relapse rate of uveitis post-methotrexate treatment in juvenile idiopathic arthritis. Am J Ophthalmol 2011;151:217–22. - PubMed

[6] Kalinina Ayuso V, van de Winkel EL, Rothova A, de Boer JH. Relapse rate of uveitis post-methotrexate treatment in juvenile idiopathic arthritis. Am J Ophthalmol 2011;151:217–22. - PubMed

[7] Saboo US, Metzinger JL, Radwan A, et al. Risk factors associated with the relapse of uveitis in patients with juvenile idiopathic arthritis: a preliminary report. J AAPOS 2013;17:460–4. - PubMed

[8] Saboo US, Metzinger JL, Radwan A, et al. Risk factors associated with the relapse of uveitis in patients with juvenile idiopathic arthritis: a preliminary report. J AAPOS 2013;17:460–4. - PubMed

[9] Acharya NR, Ebert CD, Kelly NK, et al. Discontinuing adalimumab in patients with controlled juvenile idiopathic arthritis-associated uveitis (ADJUST-Adalimumab in Juvenile Idiopathic Arthritis-associated Uveitis Stopping Trial): study protocol for a randomised controlled trial. Trials 2020;21:887. - PMC - PubMed

[10] Acharya NR, Ebert CD, Kelly NK, et al. Discontinuing adalimumab in patients with controlled juvenile idiopathic arthritis-associated uveitis (ADJUST-Adalimumab in Juvenile Idiopathic Arthritis-associated Uveitis Stopping Trial): study protocol for a randomised controlled trial. Trials 2020;21:887. - PMC - PubMed

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Relapse and Remission in Children With Chronic Noninfectious Uveitis Treated With Methotrexate

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Relapse and Remission in Children With Chronic Noninfectious Uveitis Treated With Methotrexate

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