Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Dec;47(12):993-995.
doi: 10.1016/j.tibs.2022.07.008. Epub 2022 Aug 13.

Cofactors: a new layer of specificity to enhancer regulation

Elisa Kreibich  1 , Arnaud R Krebs  2
Affiliations
Comment

Cofactors: a new layer of specificity to enhancer regulation

Elisa Kreibich et al. Trends Biochem Sci. 2022 Dec.

Abstract

Cofactors are essential effectors of the transcription control machinery. How this functionally diverse group of factors is used in the genome remains elusive. A recent study by Neumayr, Haberle et al. sheds light on this question, showing that enhancers depend on defined combinations of cofactors for their activation.

Keywords: cofactors; enhancer; gene regulation; transcription factors.

PubMed Disclaimer

Comment on

MeSH terms

Substances

LinkOut - more resources