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Comment
. 2022 Sep;609(7926):248-249.
doi: 10.1038/d41586-022-02189-7.

Structural keys unlock RAS-MAPK cellular signalling pathway

Hugo Lavoie, Marc Therrien
Comment

Structural keys unlock RAS-MAPK cellular signalling pathway

Hugo Lavoie et al. Nature. 2022 Sep.
No abstract available

Keywords: Molecular biology; Structural biology.

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Comment on

  • Structural basis for SHOC2 modulation of RAS signalling.
    Liau NPD, Johnson MC, Izadi S, Gerosa L, Hammel M, Bruning JM, Wendorff TJ, Phung W, Hymowitz SG, Sudhamsu J. Liau NPD, et al. Nature. 2022 Sep;609(7926):400-407. doi: 10.1038/s41586-022-04838-3. Epub 2022 Jun 29. Nature. 2022. PMID: 35768504 Free PMC article.
  • Structure of the MRAS-SHOC2-PP1C phosphatase complex.
    Hauseman ZJ, Fodor M, Dhembi A, Viscomi J, Egli D, Bleu M, Katz S, Park E, Jang DM, Porter KA, Meili F, Guo H, Kerr G, Mollé S, Velez-Vega C, Beyer KS, Galli GG, Maira SM, Stams T, Clark K, Eck MJ, Tordella L, Thoma CR, King DA. Hauseman ZJ, et al. Nature. 2022 Sep;609(7926):416-423. doi: 10.1038/s41586-022-05086-1. Epub 2022 Jul 13. Nature. 2022. PMID: 35830882 Free PMC article.
  • Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.
    Kwon JJ, Hajian B, Bian Y, Young LC, Amor AJ, Fuller JR, Fraley CV, Sykes AM, So J, Pan J, Baker L, Lee SJ, Wheeler DB, Mayhew DL, Persky NS, Yang X, Root DE, Barsotti AM, Stamford AW, Perry CK, Burgin A, McCormick F, Lemke CT, Hahn WC, Aguirre AJ. Kwon JJ, et al. Nature. 2022 Sep;609(7926):408-415. doi: 10.1038/s41586-022-04928-2. Epub 2022 Jul 13. Nature. 2022. PMID: 35831509 Free PMC article.

References

    1. Simanshu, D. K., Nissley, D. V. & McCormick, F. Cell 170, 17–33 (2017). - PubMed - DOI - PMC
    1. Lavoie, H., Gagnon, J. & Therrien, M. Nature Rev. Mol. Cell Biol. 21, 607–632 (2020). - PubMed - DOI
    1. Liau, N. P. D. et al. Nature 609, 400–407 (2022). - DOI
    1. Kwon, J. J. et al. Nature 609, 408–415 (2022). - DOI
    1. Hauseman, Z. J. et al. Nature 609, 416–423 (2022). - DOI

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