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Review
. 2022 Dec;25(4):289-297.
doi: 10.1007/s10047-022-01358-9. Epub 2022 Aug 15.

Nerve regeneration using the Bio 3D nerve conduit fabricated with spheroids

Ryosuke Ikeguchi  1 , Tomoki Aoyama  2 , Mai Tanaka  2 , Takashi Noguchi  3 , Maki Ando  3 , Koichi Yoshimoto  3 , Daichi Sakamoto  3 , Terunobu Iwai  3 , Yudai Miyazaki  4 , Shizuka Akieda  4 , Makoto Ikeya  5 , Koichi Nakayama  6 , Shuichi Matsuda  3
Affiliations
Review

Nerve regeneration using the Bio 3D nerve conduit fabricated with spheroids

Ryosuke Ikeguchi et al. J Artif Organs. 2022 Dec.

Abstract

Autologous nerve grafting is the gold standard method for peripheral nerve injury with defects. Artificial nerve conduits have been developed to prevent morbidity at the harvest site. However, the artificial conduit regeneration capacity is not sufficient. A Bio 3D printer is technology that creates three-dimensional tissue using only cells. Using this technology, a three-dimensional nerve conduit (Bio 3D nerve conduit) was created from several cell spheroids. We reported the first application of the Bio 3D nerve conduit for peripheral nerve injury. A Bio 3D nerve conduit that was created from several cells promotes peripheral nerve regeneration. The Bio 3D nerve conduit may be useful clinically to treat peripheral nerve defects.

Keywords: Bio 3D nerve conduit; Bio 3D printer; Nerve conduit; Peripheral nerve; Regeneration.

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