Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2022 Dec;24(12):2474-2477.
doi: 10.1111/dom.14839. Epub 2022 Sep 5.

A comparison of the effectiveness and safety of insulin glargine 300 U/ml versus 100 U/ml in children and adolescents with newly diagnosed type 1 diabetes: A retrospective, observational, short-term study

Ivana Rabbone  1 , Erica Pozzi  1 , Silvia Savastio  1 , Galimberti Luca  2 , Morotti Elisa  2 , Frontino Giulio  2 , Geremia B Bolli  3 , Riccardo Bonfanti  2
Affiliations
Observational Study

A comparison of the effectiveness and safety of insulin glargine 300 U/ml versus 100 U/ml in children and adolescents with newly diagnosed type 1 diabetes: A retrospective, observational, short-term study

Ivana Rabbone et al. Diabetes Obes Metab. 2022 Dec.
No abstract available

PubMed Disclaimer

References

REFERENCES

    1. Danne T, Tamborlane WV, Malievsky OA, et al. Efficacy and safety of insulin glargine 300 units/mL (Gla-300) versus insulin glargine 100 units/mL (Gla-100) in children and adolescents (6-17 years) with type 1 diabetes: results of the EDITION JUNIOR randomized controlled trial. Diabetes Care. 2020;43(7):1512-1519. doi:10.2337/dc19-1926
    1. Becker RH, Dahmen R, Bergmann K, Lehmann A, Jax T, Heise T. New insulin glargine 300 units · mL-1 provides a more even activity profile and prolonged glycemic control at steady state compared with insulin glargine 100 units · mL-1. Diabetes Care. 2015;38(4):637-643. doi:10.2337/dc14-0006
    1. Steinstraesser A, Schmidt R, Bergmann K, Dahmen R, Becker RH. Investigational new insulin glargine 300 U/ml has the same metabolism as insulin glargine 100 U/ml. Diabetes Obes Metab. 2014;16(9):873-876. doi:10.1111/dom.12283
    1. Werner U, Tennagels N, Fanelli CG, Bolli GB. Equipotency of insulin glargine 300 and 100 U/mL with intravenous dosing but differential bioavailability with subcutaneous dosing in dogs. Diabetes Obes Metab. 2021;23(1):166-174. doi:10.1111/dom.14212
    1. Porcellati F, Lucidi P, Candeloro P, et al. Pharmacokinetics, pharmacodynamics, and modulation of hepatic glucose production with insulin glargine U300 and glargine U100 at steady state with individualized clinical doses in type 1 diabetes. Diabetes Care. 2019;42(1):85-92. doi:10.2337/dc18-0706

Publication types

LinkOut - more resources