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Case Reports
. 2022 Jul 13;14(7):e26824.
doi: 10.7759/cureus.26824. eCollection 2022 Jul.

Rechallenging Fluoropyrimidine-Induced Cardiotoxicity and Neurotoxicity: A Report of Two Cases

Sethi Ashish  1 , Moses S Raj  1 , Dulabh Monga  1 , Gene Finley  1
Affiliations
Case Reports

Rechallenging Fluoropyrimidine-Induced Cardiotoxicity and Neurotoxicity: A Report of Two Cases

Sethi Ashish et al. Cureus. .

Abstract

Fluoropyrimidines (FP's) such as fluorouracil (5-FU) and capecitabine are antimetabolites widely used in many solid tumors. FPs side effects are caused mainly by a lack of dihydropyrimidine dehydrogenase (DPD) enzyme. It has been noticed that treatment with infusional regimens of 5-FU is associated with more adverse events (AE) compared to bolus forms. Here, we report two cases of unusual side effects seen with infusional 5-FU and capecitabine and how early intervention by withholding ongoing treatment can help in preventing progression and mortality.

Keywords: 5-fu; bolus 5-fu; capecitabine; cardiotoxicity; cerebellar infarct; infusional 5-fu.

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Conflict of interest statement

The authors have declared that no competing interests exist.

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