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. 2022 Aug 24:102:adv00763.
doi: 10.2340/actadv.v102.2690.

Propylthiouracil-induced Alopecia Accompanying Hypohidrosis and Onychomadesis

Nozomi Yanagida, Shunsuke Takahagi  1 , Akio Tanaka, Michihiro Hide
Affiliations

Propylthiouracil-induced Alopecia Accompanying Hypohidrosis and Onychomadesis

Nozomi Yanagida et al. Acta Derm Venereol. .
No abstract available

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
(a) Almost total hair loss over the scalp. (b) Onychomadesis with periungual erythema and scaling of fingers. (c) Trichoscopy showed sparse vellus hairs, broken hairs, and the sharply bended hair shafts. (d) A thermoregulatory sweat test using the starch-iodine method revealed generalized hypohidrosis distributed on 61% of the total body surface area. (e, f) Three months after discontinuation of propylthiouracil (PTU), the entire scalp and nail plate were completely recovered without treatment.
Fig. 2
Fig. 2
(a) A skin specimen from alopecia on the scalp revealed dense lymphocytic infiltration and damage to anagen hair bulbs. (b) Infiltrating lymphocytes were stained with CD3 antibody. (c, d) In the lesion of hypohidrosis on the thigh, mild atrophy in the secretary portion of eccrine sweat glands were observed with slight infiltration of CD3+ T lymphocyte. HE: haematoxylin and eosin staining: a, b ×200 and c, d ×400.
See this image and copyright information in PMC

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