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Review
. 2022 Aug 16;39(11):174.
doi: 10.1007/s12032-022-01766-0.

Clinical value and molecular mechanism of AQGPs in different tumors

Rui Wang #  1 , Xuejian Wang #  1 , Jun Zhao  2 , Jiacheng Jin  1 , Weiwei Fan  1 , Xinqing Zhu  1 , Qiwei Chen  1 , Baochang Zhang  1 , Lan Lan  1 , Kexin Qu  1 , Liang Zhu  3 , Jianbo Wang  4
Affiliations
Review

Clinical value and molecular mechanism of AQGPs in different tumors

Rui Wang et al. Med Oncol. .

Abstract

Aquaglyceroporins (AQGPs), including AQP3, AQP7, AQP9, and AQP10, are transmembrane channels that allow small solutes across biological membranes, such as water, glycerol, H2O2, and so on. Increasing evidence suggests that they play critical roles in cancer. Overexpression or knockdown of AQGPs can promote or inhibit cancer cell proliferation, migration, invasion, apoptosis, epithelial-mesenchymal transition and metastasis, and the expression levels of AQGPs are closely linked to the prognosis of cancer patients. Here, we provide a comprehensive and detailed review to discuss the expression patterns of AQGPs in different cancers as well as the relationship between the expression patterns and prognosis. Then, we elaborate the relevance between AQGPs and malignant behaviors in cancer as well as the latent upstream regulators and downstream targets or signaling pathways of AQGPs. Finally, we summarize the potential clinical value in cancer treatment. This review will provide us with new ideas and thoughts for subsequent cancer therapy specifically targeting AQGPs.

Keywords: Aquaglyceroporin; Cancer; Expression pattern; Regulator; Signaling pathway.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
a Locations of NPA boxes, membrane-spanning domains, cytoplasmic-facing terminus are shown, and two additional peptide spans are denoted by asterisks; b Hourglass model for aquaglyceroporin membrane topology
Fig. 2
Fig. 2
AQP3-mediated H2O2 promotes cancer progression via tumor-related signaling pathways
Fig. 3
Fig. 3
The upstream regulators of AQP3 and the downstream activated tumor-related signaling pathways [, –, , –, , –124]
Fig. 4
Fig. 4
The upstream regulators of AQP9 and the downstream activated tumor-related signaling pathways
See this image and copyright information in PMC

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