Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Aug 16;17(8):e0273189.
doi: 10.1371/journal.pone.0273189. eCollection 2022.

Venous thromboembolic and hemorrhagic events after meningioma surgery: A single-center retrospective cohort study of risk factors

Nebojsa Lasica  1   2 , Djula Djilvesi  1   2 , Vladimir Papic  1   2 , Mladen Karan  3 , Bojan Jelaca  1   2 , Jagos Golubovic  1   2 , Filip Pajicic  1   2 , Milica Medic-Stojanoska  2   4 , Petar Vulekovic  1   2 , Lukas Rasulic  5   6
Affiliations

Venous thromboembolic and hemorrhagic events after meningioma surgery: A single-center retrospective cohort study of risk factors

Nebojsa Lasica et al. PLoS One. .

Abstract

Microsurgical resection of meningiomas in a majority of cases leads to a favorable outcome. Therefore, severe postoperative adverse events are less acceptable. The main purpose of this study was to investigate the incidence of symptomatic venous thromboembolism (VTE) and hemorrhagic complications in patients after operative treatment of intracranial meningiomas and to identify the risk factors in this patient subgroup. Of 106 patients undergoing elective craniotomy for meningioma overall incidence of symptomatic VTE was noted in 5.7% (six patients). For the risk-factor analysis older age (57.20 ± 11.60 vs. 71.00 ± 0.90 years, p < 0.001), higher body mass index (27.60 ± 4.80 vs. 33.16 ± 0.60 kg/m2, p < 0.001), WHO grade II (3.00% vs. 33.33%, p = 0.02), lower intraoperative blood loss (466.00 ± 383.70 vs. 216.70 ± 68.30 mL, p < 0.001), bedridden status and neurologic deficit (0.00% vs. 33.33%, p = 0.003 and 38.00% vs. 100.00%, p = 0.004) were associated with greater VTE risk. No risk factors for hemorrhagic complications were identified on univariate analysis. In conclusion, the incidence of VTE in meningioma patients is not negligible. Identified risk factors should be taken into account in the decision-making process for chemoprophylaxis when the risk of bleeding decreases.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow chart of the postoperative hemorrhagic and thromboembolic complications in patients after operative treatment for intracranial meningiomas in our cohort.
Fig 2
Fig 2. Timeline of postoperative thromboembolic and hemorrhagic complications.
Most complications occur in the first postoperative week.
Fig 3
Fig 3. Between-group comparison of BMI grade of patients from the VTE and the Non-VTE group.
Patients with VTE are exclusively present in the obese group. *Values are significant with a p-value <0.05.
Fig 4
Fig 4. Between-group comparison of ambulatory status of patients in the VTE and Non-VTE group.
VTE group patients had exclusively bedridden status, and non-VTE patients were all ambulatory. *Values are significant with a p-value <0.05.
See this image and copyright information in PMC

References

    1. Wiemels J, Wrensch M, Claus EB. Epidemiology and etiology of meningioma. J Neurooncol. 2010;99: 307–314. doi: 10.1007/s11060-010-0386-3 - DOI - PMC - PubMed
    1. Sughrue ME, Rutkowski MJ, Shangari G, Chang HQ, Parsa AT, Berger MS, et al.. Risk factors for the development of serious medical complications after resection of meningiomas. Clinical article. J Neurosurg. 2011;114: 697–704. doi: 10.3171/2010.6.JNS091974 - DOI - PubMed
    1. Sjåvik K, Bartek J Jr., Solheim O, Ingebrigtsen T, Gulati S, Sagberg LM, et al.. Venous thromboembolism prophylaxis in meningioma surgery: A population-based comparative effectiveness study of routine mechanical prophylaxis with or without preoperative low-molecular-weight heparin. World Neurosurg. 2016;88: 320–326. doi: 10.1016/j.wneu.2015.12.077 - DOI - PubMed
    1. Levi AD, Wallace MC, Bernstein M, Walters BC. Venous thromboembolism after brain tumor surgery: A retrospective review. Neurosurgery. 1991;28: 859–863. doi: 10.1097/00006123-199106000-00012 - DOI - PubMed
    1. Anthofer J, Wester M, Zeman F, Brawanski A, Schebesch KM. Case-control study of patients at risk of medical complications after elective craniotomy. World Neurosurg. 2016;91: 58–65. doi: 10.1016/j.wneu.2016.03.087 - DOI - PubMed

MeSH terms