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Review
. 2022 Summer;13(3):447-457.
doi: 10.22088/cjim.13.3.447.

Global systematic review and meta-analysis of health-related quality of life in Behcet's patients

Maryam Masoumi  1 , Alireza Sharifi  1 , Sepideh Rezaei  2 , Sima Rafiei  3 , Hossein Hosseinifard  4 , Saghar Khani  5 , Maryam Doustmehraban  3 , Mona Rajabi  3 , Zahra Beiramy Chomalou  6 , Parisa Soori  6 , Akbar Javan Biparva  7 , Afsaneh Dehnad  8 , Fatemeh Pashazadeh Kan  6 , Ahmad Ghashghaee  9
Affiliations
Review

Global systematic review and meta-analysis of health-related quality of life in Behcet's patients

Maryam Masoumi et al. Caspian J Intern Med. 2022 Summer.

Abstract

Background: Behcet's disease (BD) is a chronic fatal illness with a relapsing remitting nature and significant organ-threatening morbidity and mortality. The aim of this research was to examine studies which were conducted on investigation of prevalence of quality of life among patients with Behcet's disease.

Methods: A total of 13 articles were extracted from four main databases including PubMed, EMBASE, Scopus, and Web of Science from the onset of 2000 to January 2021. All studies published in English with the purpose of examining quality of life (QOL) among patients with BD or investigating its main determinants were included.

Results: Totally, 1137 BD patients participated in 13 studies. Based on random effect analysis, the total score of physical health-related QOL was 46.7 (95% CI=41.26 to 52.13) and the total score of mental health-related QOL was 49.01 (95% CI=43.83 to 54.18) representing a moderate level of QOL among BD patients. Furthermore, weighted effect size analyses showed a significant correlation between QOL and variables such as patients' age, gender, disease duration and depression (pvalue: 0.00).

Conclusion: As the symptoms of BD worsen over time, patients confront with more severe body pain, mobility restrictions, and difficulties in chewing, eating, speaking and swallowing which negatively affect social interactions of patients and reduce their QOL. Furthermore, depression was proved to act as a deteriorating factor for Health-Related Quality of Life (HRQOL) among BD patients. Thus, patients need to be psychologically supported by a specialized team and be informed during the course of treatment to gain useful information about the disease, treatment approaches and coping strategies.

Keywords: Behcet’s disease; HRQOL; Health-related quality of life; Old Silk Route disease.

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Conflict of interest statement

The authors declare that they have no competing interests

Figures

Figure 1
Figure 1
Flow diagram of review process (PRISMA)
Figure 2
Figure 2
Forest plots of both physical and mental health-related quality of life (HRQOL)
Figure 3
Figure 3
Meta-regression based on age
Figure 4
Figure 4
Meta-regression based on duration of disease
Figure 5
Figure 5
Meta-regression based on depression
Figure 6
Figure 6
Meta-regression based on year
Figure 7
Figure 7
Meta-regression based on gender
See this image and copyright information in PMC

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