Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987;113(4):359-62.
doi: 10.1007/BF00397719.

Combined immunostimulation (Propionibacterium avidum KP 40) and anticoagulation (heparin) prevents metastatic lung and liver colonization in mice

J Beuth, H L Ko, G Uhlenbruck, G Pulverer

Combined immunostimulation (Propionibacterium avidum KP 40) and anticoagulation (heparin) prevents metastatic lung and liver colonization in mice

J Beuth et al. J Cancer Res Clin Oncol. 1987.

Abstract

The antineoplastic activity of Propionibacterium avidum KP-40 and its enhancement by anticoagulation with heparin was studied. In Balb/c mice syngeneic sarcoma L-1 exclusively caused tumor colonization of the lungs. After neuraminidase treatment the organotropism of this tumor was changed, with tumor nodules developing in lung and liver. After single systemic application of Propionibacterium avidum KP-40 the number of lung and liver colonies decreased evidently. Combination of this immunomodulating therapy with temporary anticoagulation resulted in further reduction of tumor colonies in lung and liver.

PubMed Disclaimer

References

    1. Badenoch-Jones P, Ramshaw JA (1985) Characterization of rat tumor cell hybrids: procoagulant and fibrinolytic activities. Aust J Exp Biol Med Sci 63:91–98 - PubMed
    1. Beuth J, Uhlenbruck G (1985) Leber-Lektine als Mediatoren der Metastasierung maligner Tumoren. Funkt Biol Med 5:269–275
    1. Beuth J, Oette K, Uhlenbruck G (1986) Liver lectins as receptors for tumor cells in metastasis. In: van Driesche E, Bog-Hansen TC (eds) Lectins, vol 5. Walter de Gruyter, Berlin, pp 229–237
    1. Beuth J, Ko HL, Oette K, Pulverer G, Roszkowski K, Uhlenbruck G (1987) Inhibition of liver metastasis in mice by blocking of hepatocyte lectins with arabinogalactan infusions and D-galactose. J Cancer Res Clin Oncol 113:51–55 - PMC - PubMed
    1. Chew EC, Wallace AC (1976) Demonstration of fibrin in early states of experimental metastases. Cancer Res 36:1904–1909 - PubMed

Publication types

MeSH terms

LinkOut - more resources