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. 2022 Dec;54(1):2259-2268.
doi: 10.1080/07853890.2022.2110277.

The association between non-alcoholic fatty liver disease (NAFLD) and advanced fibrosis with blood selenium level based on the NHANES 2017-2018

Jie Liu  1 , Liao Tan  2 , Zhaoya Liu  3 , Ruizheng Shi  1
Affiliations

The association between non-alcoholic fatty liver disease (NAFLD) and advanced fibrosis with blood selenium level based on the NHANES 2017-2018

Jie Liu et al. Ann Med. 2022 Dec.

Abstract

Background & objective: Selenium was one of the essential trace elements that played a pivotal role in human health. Although previous studies have investigated the relationship between selenium and non-alcoholic fatty liver disease (NAFLD) and fibrosis, these findings were still inconclusive. Our study was aimed to explore the association between blood selenium level and NAFLD and advanced liver fibrosis diagnosed by vibration controlled transient elastography (VCTE) in US adults.

Methods: All data were extracted from National Health and Nutrition Examination Survey database (2017-2018). Participants were divided into four groups according to quartile of blood selenium level. Liver stiffness and controlled attenuation parameter (CAP) were measured by VCTE. Multiple logistic regression models and subgroup analyses were conducted to determine the association between blood selenium level and NAFLD and advanced liver fibrosis diagnosed by a variety of methods.

Results: A total of 3336 participants were enrolled in main analysis. In multiple logistic regression models, the higher blood selenium level (>205.32, ≤453.62 μg/L) had a significant positive association with NAFLD (β = 1.31). Moreover, high blood selenium level had significantly inversely association to advanced liver fibrosis (β = 0.61). In subgroup analysis, the main inversely correlation between blood selenium and advanced liver fibrosis was found in males with high blood selenium level. Despite dietary selenium intake being adjusted or in different subgroups, the associations between blood selenium level and NAFLD/advanced liver fibrosis remained significant.

Conclusions: This study showed that blood selenium level were positively association with NAFLD among US population. Participants with lower blood selenium level showed a higher percentage of advanced liver fibrosis. Blood selenium is more likely to cause NAFLD and liver fibrosis due to imbalances in selenium homeostasis rather than dietary selenium intake.Key messagesHigh blood selenium level was association with NAFLD diagnosed by vibration controlled transient elastography.Participants with lower blood selenium level had high percentage of advanced liver fibrosis.NAFLD and liver fibrosis are caused by an imbalance of selenium homeostasis, not by dietary selenium intake.

Keywords: NAFLD; NHANES; National Health and Nutrition Examination Survey; Non-alcoholic fatty liver disease; advanced liver fibrosis; blood selenium level.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

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Figure 1.
Study flowchart.
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References

    1. Estes C, Razavi H, Loomba R, et al. . Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease[J]. Hepatology. 2018;67(1):123–133. - PMC - PubMed
    1. Huang DQ, El-Serag HB, Loomba R.. Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention[J]. Nat Rev Gastroenterol Hepatol. 2021;18(4):223–238. - PMC - PubMed
    1. Friedman SL, Neuschwander-Tetri BA, Rinella M, et al. . Mechanisms of NAFLD development and therapeutic strategies[J]. Nat Med. 2018;24(7):908–922. - PMC - PubMed
    1. Pierantonelli I, Svegliati-Baroni G.. Nonalcoholic fatty liver disease: Basic pathogenetic mechanisms in the progression from NAFLD to NASH[J]. Transplantation. 2019;103(1):e1–e13. - PubMed
    1. Argo CK, Caldwell SH.. Epidemiology and natural history of non-alcoholic steatohepatitis[J]. Clin Liver Dis. 2009;13(4):511–531. - PubMed

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