Fungal exposome, human health, and unmet needs: A 2022 update with special focus on allergy

Joana Vitte^{1

2}, Moïse Michel^{1

2

3}, Andrei Malinovschi⁴, Marco Caminati⁵, Adeyinka Odebode⁶, Isabella Annesi-Maesano¹, Davide Paolo Caimmi^{1

7}, Carole Cassagne⁸, Pascal Demoly^{1

7}, Enrico Heffler^{9

10}, Estelle Menu⁸, Bright I Nwaru^{11

12}, Youssouf Sereme^{2

13}, Stéphane Ranque⁸, Monika Raulf¹⁴, Wojciech Feleszko¹⁵, Christer Janson¹⁶, Carmen Galán^{17

18}; EAACI Task Force on Allergic Bronchopulmonary Aspergillosis

Affiliations

¹ IDESP, University of Montpellier and INSERM, Montpellier, France.
² MEPHI, IHU Méditerranée Infection, IRD, APHM, Aix-Marseille Univ, Marseille, France.
³ Immunology Laboratory, University Hospital Nîmes, Nîmes, France.
⁴ Department of Medical Sciences Clinical Physiology, Uppsala University, Uppsala, Sweden.
⁵ Asthma, Allergy and Clinical Immunology Section, Department of Medicine, University of Verona, Verona, Italy.
⁶ Department of Basic Science, Kampala International University, Kampala, Uganda.
⁷ Departement of Pneumology, University Hospital of Montpellier, Montpellier, France.
⁸ VITROME, IHU Méditerranée Infection, IRD, APHM, Aix-Marseille Univ, Marseille, France.
⁹ Personalized Medicine, Asthma and Allergy Humanitas Clinical and Research Center IRCCS Rozzano, Rozzano, Italy.
¹⁰ Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
¹¹ Krefting Research Centre, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
¹² Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.
¹³ Department of Immunology, Infectiology and Hematology, Institut Necker-Enfants Malades (INEM), INSERM U1151, CNRS UMR 8253, Université Paris Descartes, Paris, France.
¹⁴ Department of Allergology and Immunology, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany.
¹⁵ Department of Pediatric Pulmonology and Allergy, Medical University of Warsaw, Warsaw, Poland.
¹⁶ Department of Medical Sciences Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
¹⁷ International Campus of Excellence on Agrifood (ceiA3), University of Cordoba, Córdoba, Spain.
¹⁸ Andalusian Inter-University Institute for Earth System Research (IISTA), University of Cordoba, Córdoba, Spain.

PMID: 35976185
DOI: 10.1111/all.15483

Review

Fungal exposome, human health, and unmet needs: A 2022 update with special focus on allergy

Joana Vitte et al. Allergy. 2022 Nov.

. 2022 Nov;77(11):3199-3216.

doi: 10.1111/all.15483. Epub 2022 Sep 1.

Authors

Affiliations

¹ IDESP, University of Montpellier and INSERM, Montpellier, France.
² MEPHI, IHU Méditerranée Infection, IRD, APHM, Aix-Marseille Univ, Marseille, France.
³ Immunology Laboratory, University Hospital Nîmes, Nîmes, France.
⁴ Department of Medical Sciences Clinical Physiology, Uppsala University, Uppsala, Sweden.
⁵ Asthma, Allergy and Clinical Immunology Section, Department of Medicine, University of Verona, Verona, Italy.
⁶ Department of Basic Science, Kampala International University, Kampala, Uganda.
⁷ Departement of Pneumology, University Hospital of Montpellier, Montpellier, France.
⁸ VITROME, IHU Méditerranée Infection, IRD, APHM, Aix-Marseille Univ, Marseille, France.
⁹ Personalized Medicine, Asthma and Allergy Humanitas Clinical and Research Center IRCCS Rozzano, Rozzano, Italy.
¹⁰ Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
¹¹ Krefting Research Centre, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
¹² Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.
¹³ Department of Immunology, Infectiology and Hematology, Institut Necker-Enfants Malades (INEM), INSERM U1151, CNRS UMR 8253, Université Paris Descartes, Paris, France.
¹⁴ Department of Allergology and Immunology, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany.
¹⁵ Department of Pediatric Pulmonology and Allergy, Medical University of Warsaw, Warsaw, Poland.
¹⁶ Department of Medical Sciences Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
¹⁷ International Campus of Excellence on Agrifood (ceiA3), University of Cordoba, Córdoba, Spain.
¹⁸ Andalusian Inter-University Institute for Earth System Research (IISTA), University of Cordoba, Córdoba, Spain.

PMID: 35976185
DOI: 10.1111/all.15483

Abstract

Humans inhale, ingest, and touch thousands of fungi each day. The ubiquity and diversity of the fungal kingdom, reflected by its complex taxonomy, are in sharp contrast with our scarce knowledge about its distribution, pathogenic effects, and effective interventions at the environmental and individual levels. Here, we present an overview of salient features of fungi as permanent players of the human exposome and key determinants of human health, through the lens of fungal allergy and other fungal hypersensitivity reactions. Improved understanding of the fungal exposome sheds new light on the epidemiology of fungal-related hypersensitivity diseases, their immunological substratum, the currently available methods, and biomarkers for environmental and medical fungi. Unmet needs are described and potential approaches are highlighted as perspectives.

Keywords: allergic bronchopulmonary aspergillosis; allergy; exposome; fungus; hypersensitivity.

PubMed Disclaimer

References

REFERENCES

1. Raulf M, Buters J, Chapman M, et al. Monitoring of occupational and environmental aeroallergens - EAACI position paper. Allergy. 2014;69:1280-1299.
1. Prescott SL, Logan AC, Bristow J, et al. Exiting the Anthropocene: achieving personal and planetary health in the 21st century. Allergy. 2022. doi:10.1111/all.15419
1. Cecchi L, D'Amato G, Annesi-Maesano I. External exposome and allergic respiratory and skin diseases. J Allergy Clin Immunol. 2018;141:846-857.
1. Crameri R, Garbani M, Rhyner C, Huitema C. Fungi: the neglected allergenic sources. Allergy. 2014;69:176-185.
1. Radzikowska U, Baerenfaller K, Cornejo-Garcia JA, et al. Omics technologies in allergy and asthma research: An EAACI position paper. Allergy. 2022. doi:10.1111/all.15412

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- Ovid Technologies, Inc.
- Wiley
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Fungal exposome, human health, and unmet needs: A 2022 update with special focus on allergy

Affiliations

Fungal exposome, human health, and unmet needs: A 2022 update with special focus on allergy

Authors

Affiliations

Abstract

References

REFERENCES

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical