A new chapter in lipid signaling and kidney fibrosis

Affiliations

¹ Division of Nephrology, Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical School, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.

Comment

Temitayo O Idowu et al. Sci Transl Med. 2022.

. 2022 Aug 17;14(658):eadd2826.

doi: 10.1126/scitranslmed.add2826. Epub 2022 Aug 17.

¹ Division of Nephrology, Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical School, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.

Abstract

The perivascular sphingosine 1-phosphate signaling axis may be an emerging therapeutic target for treating chronic kidney disease (Tanaka et al.).

Sphingosine 1-phosphate signaling in perivascular cells enhances inflammation and fibrosis in the kidney.
Tanaka S, Zheng S, Kharel Y, Fritzemeier RG, Huang T, Foster D, Poudel N, Goggins E, Yamaoka Y, Rudnicka KP, Lipsey JE, Radel HV, Ryuh SM, Inoue T, Yao J, Rosin DL, Schwab SR, Santos WL, Lynch KR, Okusa MD. Tanaka S, et al. Sci Transl Med. 2022 Aug 17;14(658):eabj2681. doi: 10.1126/scitranslmed.abj2681. Epub 2022 Aug 17. Sci Transl Med. 2022. PMID: 35976996 Free PMC article.