Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Aug 18;60(11):1745-1752.
doi: 10.1515/cclm-2022-0559. Print 2022 Oct 26.

Early predictors of abnormal MRI patterns in asphyxiated infants: S100B protein urine levels

Iliana Bersani  1 , Giorgia Gasparroni  2 , Moataza Bashir  3 , Hanna Aboulgar  3 , Hala Mufeed  3 , Iman Iskander  3 , Maria Kornacka  4 , Darek Gruzfeld  4 , Andrea Dotta  1 , Francesca Campi  1 , Daniela Longo  5 , Immacolata Savarese  1 , Annabella Braguglia  1 , Lucia Gabriella Tina  6 , Francesco Nigro  6 , Laura Serpero  7 , Maria Chiara Strozzi  7 , Antonio Maconi  7 , Patrizia Ianniello  7 , Caterina Di Battista  2 , Ebe D'Adamo  2 , Danilo Gavilanes  8 , Diego Gazzolo  2
Affiliations

Early predictors of abnormal MRI patterns in asphyxiated infants: S100B protein urine levels

Iliana Bersani et al. Clin Chem Lab Med. .

Abstract

Objectives: The early detection and stratification of asphyxiated infants at higher risk for impaired neurodevelopment is challenging. S100B protein is a well-established biomarker of brain damage, but lacks conclusive validation according to the "gold standard" methodology for hypoxic-ischemic encephalopathy (HIE) prognostication, i.e. brain MRI. The aim of the present study was to investigate the predictive role of urinary S100B concentrations, assessed in a cohort of HIE infants receiving therapeutic hypothermia (TH), compared to brain MRI.

Methods: Assessment of urine S100B concentrations was performed by immunoluminometric assay at first void and at 4, 8, 12, 16, 20, 24, 48, 72, 96, 108 and 120-h after birth. Neurologic evaluation, routine laboratory parameters, amplitude-integrated electroencephalography, and cerebral ultrasound were performed according to standard protocols. Brain MRI was performed at 7-10 days of life.

Results: Overall, 74 HIE neonates receiving TH were included in the study. S100B correlated, already at first void, with the MRI patterns with higher concentrations in infants with the most severe MRI lesions.

Conclusions: High S100B urine levels soon after birth constitute trustable predictors of brain injury as confirmed by MRI. Results support the reliability of S100B in clinical daily practice and open the way to its inclusion in the panel of parameters used for the selection of cases suitable for TH treatment.

Keywords: S100B; brain damage; hypothermia; hypoxic ischemic encephalopathy; perinatal asphyxia.

PubMed Disclaimer

References

    1. Serpero, LD, Bellissima, V, Colivicchi, M, Sabatini, M, Frigiola, A, Ricotti, A, et al.. Next generation biomarkers for brain injury. J Matern Fetal Neonatal Med 2013;26:44–9. https://doi.org/10.3109/14767058.2013.829688.
    1. Gazzolo, D, Pluchinotta, F, Lapergola, G, Franchini, S. The Ca2+binding S100B protein: an important diagnostic and prognostic neurobiomarker in pediatric laboratory medicine. Methods Mol Biol 2019;1929:701–28.
    1. Michetti, F, Corvino, V, Geloso, MC, Lattanzi, W, Bernardini, C, Serpero, L, et al.. The S100B protein in biological fluids: more than a lifelong biomarker of brain distress. J Neurochem 2012;120:644–59. https://doi.org/10.1111/j.1471-4159.2011.07612.x.
    1. Bersani, I, Pluchinotta, F, Dotta, A, Savarese, I, Campi, F, Auriti, C, et al.. Early predictors of perinatal brain damage: the role of neurobiomarkers. Clin Chem Lab Med 2020;58:471–86. https://doi.org/10.1515/cclm-2019-0725.
    1. Gazzolo, D, Abella, R, Marinoni, E, di Iorio, R, Volti, GL, Galvano, F, et al.. New markers of neonatal neurology. J Matern Fetal Neonatal Med 2009;22:57–61. https://doi.org/10.1080/14767050903181468.

MeSH terms

Substances

LinkOut - more resources