Race, ancestry, and genetic risk for kidney failure

Susanne B Nicholas¹, Chandra L Ford², Keith C Norris³

Affiliations

¹ Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
² Department of Community Health Sciences, University of California, Los Angeles School of Public Health, Los Angeles, CA, USA; Center for the Study of Racism, Social Justice & Health, University of California, Los Angeles School of Public Health, Los Angeles, CA, USA.
³ Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Center for the Study of Racism, Social Justice & Health, University of California, Los Angeles School of Public Health, Los Angeles, CA, USA. Electronic address: kcnorris@mednet.ucla.edu.

PMID: 35977464
PMCID: PMC9418843
DOI: 10.1016/j.xcrm.2022.100726

Comment

Race, ancestry, and genetic risk for kidney failure

Susanne B Nicholas et al. Cell Rep Med. 2022.

. 2022 Aug 16;3(8):100726.

doi: 10.1016/j.xcrm.2022.100726.

Authors

Susanne B Nicholas¹, Chandra L Ford², Keith C Norris³

Affiliations

¹ Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
² Department of Community Health Sciences, University of California, Los Angeles School of Public Health, Los Angeles, CA, USA; Center for the Study of Racism, Social Justice & Health, University of California, Los Angeles School of Public Health, Los Angeles, CA, USA.
³ Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Center for the Study of Racism, Social Justice & Health, University of California, Los Angeles School of Public Health, Los Angeles, CA, USA. Electronic address: kcnorris@mednet.ucla.edu.

PMID: 35977464
PMCID: PMC9418843
DOI: 10.1016/j.xcrm.2022.100726

Abstract

In a retrospective analysis of over 62,000 Black and non-Black participants from eight United States cohorts, Gutiérrez et al.¹ examined estimated glomerular filtration rate (eGFR) equations to assess racial differences in kidney failure requiring replacement therapy and in mortality across different equations.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

Association of Estimated GFR Calculated Using Race-Free Equations With Kidney Failure and Mortality by Black vs Non-Black Race.
Gutiérrez OM, Sang Y, Grams ME, Ballew SH, Surapaneni A, Matsushita K, Go AS, Shlipak MG, Inker LA, Eneanya ND, Crews DC, Powe NR, Levey AS, Coresh J; Chronic Kidney Disease Prognosis Consortium. Gutiérrez OM, et al. JAMA. 2022 Jun 21;327(23):2306-2316. doi: 10.1001/jama.2022.8801. JAMA. 2022. PMID: 35667006 Free PMC article.

References

1. Gutiérrez O.M., Sang Y., Grams M.E., Ballew S.H., Surapaneni A., Matsushita K., Go A.S., Shlipak M.G., Inker L.A., Eneanya N.D., et al. Association of estimated GFR Calculated using race-free equations with kidney failure and mortality by Black vs non-Black race. JAMA, J. Am. Med. Assoc. 2022;327:2306. doi: 10.1001/jama.2022.8801. - DOI - PMC - PubMed
1. Thurlow J.S., Joshi M., Yan G., Norris K.C., Agodoa L.Y., Yuan C.M., Nee R. Global Epidemiology of End-Stage kidney disease and disparities in kidney replacement therapy. Am. J. Nephrol. 2021;52:98–107. doi: 10.1159/000514550. - DOI - PMC - PubMed
1. Improving Global Outcomes (KDIGO) CKD Work Group KDIGO 2012 clinical practice Guideline for the Evaluation and Management of Chronic kidney disease. Kidney Int. 2012;2:337–414.
1. Levey A.S., Bosch J.P., Lewis J.B., Greene T., Rogers N., Roth D. A more Accurate method to estimate glomerular filtration rate from Serum creatinine: a new prediction equation. Ann. Intern. Med. 1999;130:461. doi: 10.7326/0003-4819-130-6-199903160-00002. - DOI - PubMed
1. Kuehn B.M., Seaborg E. Medical students lead effort to remove race from kidney function estimates. Kidney News. 2020;12:1–3.

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Race, ancestry, and genetic risk for kidney failure

Affiliations

Race, ancestry, and genetic risk for kidney failure

Authors

Affiliations

Abstract

Conflict of interest statement

Comment on

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical

Research Materials

Miscellaneous