Like mother, like child: The maternal microbiome impacts offspring asthma
- PMID: 35977469
- PMCID: PMC9418848
- DOI: 10.1016/j.xcrm.2022.100722
Like mother, like child: The maternal microbiome impacts offspring asthma
Abstract
The link between the maternal microbiome and offspring allergy is poorly defined. McCauley and colleagues now demonstrate that heritable bacteria are associated with infant asthma susceptibility and induce immunosuppression of allergic inflammation, suggesting significant implications for asthma-preventative interventions1.
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
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References
-
- Boutin R.C., Sbihi H., Dsouza M., Malhotra R., Petersen C., Dai D., Sears M.R., Moraes T.J., Becker A.B., Azad M.B., Mandhane P.J. Mining the infant gut microbiota for therapeutic targets against atopic disease. Allergy. 2020;75:2065–2068. - PubMed
-
- Arrieta M.C., Stiemsma L.T., Dimitriu P.A., Thorson L., Russell S., Yurist-Doutsch S., Kuzeljevic B., Gold M.J., Britton H.M., Lefebvre D.L., Subbarao P. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci. Transl. Med. 2015:7. 307ra152. - PubMed
-
- Gao Y., Nanan R., Macia L., Tan J., Sominsky L., Quinn T.P., O’Hely M., Ponsonby A.L., Tang M.L., Collier F., Strickland D.H. The maternal gut microbiome during pregnancy and offspring allergy and asthma. J. Allergy Clin. Immunol. 2021;148:669–678. - PubMed