Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Aug 16;3(8):100722.
doi: 10.1016/j.xcrm.2022.100722.

Like mother, like child: The maternal microbiome impacts offspring asthma

Affiliations

Like mother, like child: The maternal microbiome impacts offspring asthma

Isabel Tarrant et al. Cell Rep Med. .

Abstract

The link between the maternal microbiome and offspring allergy is poorly defined. McCauley and colleagues now demonstrate that heritable bacteria are associated with infant asthma susceptibility and induce immunosuppression of allergic inflammation, suggesting significant implications for asthma-preventative interventions1.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1
Figure 1
The link between prenatal factors, the maternal and infant microbiome, and subsequent offspring asthma

Similar articles

Cited by

References

    1. McCauley K.E., Rackaityte E., LaMere B., Fadrosh D.W., Fujimura K.E., Panzer A.R., et al. Heritable Vaginal Bacteria Promote Immune Tolerance and Relate to Early-Life Markers of Allergic Sensitization in Infancy. Cell Reports. 2022;8 - PMC - PubMed
    1. Qian L.J., Kang S.M., Xie J.L., Huang L., Wen Q., Fan Y.Y., Lu L.J., Jiang L. Early-life gut microbial colonization shapes Th1/Th2 balance in asthma model in BALB/c mice. BMC Microbiol. 2017;17:1–8. - PMC - PubMed
    1. Boutin R.C., Sbihi H., Dsouza M., Malhotra R., Petersen C., Dai D., Sears M.R., Moraes T.J., Becker A.B., Azad M.B., Mandhane P.J. Mining the infant gut microbiota for therapeutic targets against atopic disease. Allergy. 2020;75:2065–2068. - PubMed
    1. Arrieta M.C., Stiemsma L.T., Dimitriu P.A., Thorson L., Russell S., Yurist-Doutsch S., Kuzeljevic B., Gold M.J., Britton H.M., Lefebvre D.L., Subbarao P. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci. Transl. Med. 2015:7. 307ra152. - PubMed
    1. Gao Y., Nanan R., Macia L., Tan J., Sominsky L., Quinn T.P., O’Hely M., Ponsonby A.L., Tang M.L., Collier F., Strickland D.H. The maternal gut microbiome during pregnancy and offspring allergy and asthma. J. Allergy Clin. Immunol. 2021;148:669–678. - PubMed