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. 2022 Aug 16;3(8):100724.
doi: 10.1016/j.xcrm.2022.100724.

Regenerative medicine meets translational oncology: Modeling leukemic bone marrow niche

Natalia Borbaran-Bravo  1 , Patricia Arreba-Tutusaus  1 , Malte U Ritter  1 , Masoud Nasri  1 , Maksim Klimiankou  1 , Julia Skokowa  2
Affiliations

Regenerative medicine meets translational oncology: Modeling leukemic bone marrow niche

Natalia Borbaran-Bravo et al. Cell Rep Med. .

Abstract

Most studies on leukemia focus on leukemia cells as isolated objects without considering the bone marrow niche. Pal et al. have recreated the bone marrow niche using induced pluripotent stem cells (iPSCs), identifying CDH2 as a therapeutically druggable leukemia-promoting factor.1.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1
Figure 1
Leukemia cell interaction with bone marrow niche components via N-cadherin causes therapy resistance Image created with BioRender.com.
See this image and copyright information in PMC

References

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