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Multicenter Study
. 2022 Sep;37(5):1002-1010.
doi: 10.3904/kjim.2022.070. Epub 2022 Aug 18.

Prevalence of chronic rhinosinusitis and its relating factors in patients with bronchiectasis: findings from KMBARC registry

Iseul Yu  1 , Suk Joong Yong  1 , Won-Yeon Lee  1 , Sang-Ha Kim  1 , Hyun Lee  2 , Ju Ock Na  3 , Deog Kyeom Kim  4 , Yeon-Mok Oh  5 , Ji-Ho Lee  1 ; KMBARC
Affiliations
Multicenter Study

Prevalence of chronic rhinosinusitis and its relating factors in patients with bronchiectasis: findings from KMBARC registry

Iseul Yu et al. Korean J Intern Med. 2022 Sep.

Abstract

Background/aims: Patients with bronchiectasis often present with respiratory symptoms caused by chronic rhinosinusitis (CRS). However, studies on the prevalence of CRS and its relationship with bronchiectasis are limited.

Methods: The baseline characteristics of patients with bronchiectasis recruited from the Korean Multicenter Bronchiectasis Audit and Research Collaboration were analyzed. CRS diagnosis was determined by a physician, on the basis of medical records, upper airway symptoms, and/or radiologic abnormalities. Questionnaires for quality of life, fatigue, and depression were administered when patients were stable for a minimum of 4 weeks after the bronchiectasis exacerbation.

Results: The prevalence of CRS was 7.1% (66/931). Patients with CRS were significantly younger than those without CRS (60.5 ± 10.7 years vs. 64.6 ± 9.3 years, p = 0.001). Idiopathic bronchiectasis was more common in patients with CRS compared to those without CRS (53.0% vs. 36.0%, p = 0.006). Lung function, inflammatory markers, exacerbations, bronchiectasis severity, and scores for quality of life, fatigue, and depression did not differ between the two groups. In a logistic regression analysis, CRS was associated with age of bronchiectasis diagnosis (odds ratio [OR], 0.96; 95% confidence interval [CI], 0.94 to 0.99; p = 0.003) and idiopathic bronchiectasis (OR, 1.95; 95% CI, 1.12 to 3.34; p = 0.018).

Conclusion: The prevalence of CRS was relatively low. CRS was not associated with the severity or clinical outcomes of bronchiectasis. Early diagnosis and idiopathic etiology were associated with CRS. Our findings reflect the low recognition of CRS in the clinical practice of bronchiectasis and highlight the need for awareness of CRS by adopting objective diagnostic criteria.

Keywords: Bronchiectasis; Etiology; Idiopathic; Sinusitis.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1
Comparison of forced expiratory volume in 1 second % (FEV1%) predicted (A) and blood eosinophil count (B) according to the presence of chronic rhinosinusitis (CRS).
Figure 2
Figure 2
Results of three patient-reported outcomes. (A) Bronchiectasis Health Questionnaire, (B) Fatigue Severity Score, and (C) Patient Health Questionnaire 9 are compared between patients with and without chronic rhinosinusitis (CRS).
Figure 3
Figure 3
Severity of bronchiectasis classified by (A) bronchiectasis severity index (BSI) and (B) FACED are compared between patients with and without chronic rhinosinusitis (CRS).
Figure 4
Figure 4
Odds ratios predictive of chronic rhinosinusitis in a multivariable analysis. FEV1%, forced expiratory volume in 1 second %; CI, confidence interval. aAll variables presented in figure were adjusted.
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