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. 2022 Aug 17;12(1):13969.
doi: 10.1038/s41598-022-18197-6.

Correlation analysis of metabolic characteristics and the risk of metabolic-associated fatty liver disease - related hepatocellular carcinoma

Xuancheng Xie  1 , Mengyao Zheng  1 , Weibo Guo  1 , Ying Zhou  1 , Zhao Xiang  1 , Yuting Li  1 , Jinhui Yang  2
Affiliations

Correlation analysis of metabolic characteristics and the risk of metabolic-associated fatty liver disease - related hepatocellular carcinoma

Xuancheng Xie et al. Sci Rep. .

Abstract

Metabolic-associated fatty liver disease (MAFLD) is currently the most common chronic liver disease worldwide and the main cause of hepatocellular carcinoma (HCC). To explore the risk factors of MAFLD-HCC, we evaluated the independent and combined effects of metabolic characteristics on the risk of MAFLD-HCC. We retrospectively analyzed 135 MAFLD-HCC patients who were treated at the Second Affiliated Hospital of Kunming Medical University from January 2015 to December 2020 and 135 MAFLD patients as the control group. Independent and joint effects of metabolic traits on the risk of HCC were evaluated. Each metabolic feature was significantly correlated with the increased risk of MAFLD-HCC (p < 0.05); obesity had the strongest correlation (adjusted odds ratio [OR] 3.63, 95% confidence interval [CI] 1.99-6.62). In patients with superimposed features, HCC risk was higher with more metabolic features (p < 0.05). The correlation between metabolic characteristics and risk of MAFLD-HCC in patients without cirrhosis or advanced fibrosis was basically consistent with the overall analysis. Metabolic characteristics increase the risk of MAFLD-HCC, and the risk is positively correlated with the number of metabolic characteristics. Obesity has the strongest correlation with HCC.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Flowchart of the study. MAFLD metabolic-associated fatty liver disease, MAFLD-HCC metabolic-associated fatty liver disease related hepatocellular carcinoma.
Figure 2
Figure 2
Adjusted associations between metabolic traits and MAFLD-HCC on multivariate logistic regression analysis. T2 DM type II diabetes.
Figure 3
Figure 3
Adjusted associations between the number of metabolic traits and MAFLD-HCC on multivariate logistic regression analysis.
See this image and copyright information in PMC

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References

    1. Eslam M, Sanyal AJ, George J. MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease. Gastroenterology. 2020;158:1999–2014. doi: 10.1053/j.gastro.2019.11.312. - DOI - PubMed
    1. Valery PC, et al. Projections of primary liver cancer to 2030 in 30 countries worldwide. Hepatology. 2018;67:600–611. doi: 10.1002/hep.29498. - DOI - PMC - PubMed
    1. Fan JG, Kim SU, Wong VW. New trends on obesity and NAFLD in Asia. J. Hepatol. 2017;67:62–873. doi: 10.1016/j.jhep.2017.06.003. - DOI - PubMed
    1. Singal AG, Lampertico P, Nahon P. Epidemiology and surveillance for hepatocellular carcinoma: New trends. J. Hepatol. 2020;72:250–261. doi: 10.1016/j.jhep.2019.08.025. - DOI - PMC - PubMed
    1. Chen VL, et al. Effects of cirrhosis and diagnosis scenario in metabolic-associated fatty liver disease-related hepatocellular carcinoma. Hepatol. Commun. 2021;5:122–132. doi: 10.1002/hep4.1606. - DOI - PMC - PubMed

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