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. 2017 Jun:4:28-34.
doi: 10.1016/j.cotox.2017.03.003.

The need for non- or minimally-invasive biomonitoring strategies and the development of pharmacokinetic/pharmacodynamic models for quantification

Charles Timchalk  1 , Thomas J Weber  1 , Jordan N Smith  1
Affiliations

The need for non- or minimally-invasive biomonitoring strategies and the development of pharmacokinetic/pharmacodynamic models for quantification

Charles Timchalk et al. Curr Opin Toxicol. 2017 Jun.

Abstract

Advancements in Exposure Science involving the development and deployment of biomarkers of exposure and biological response are anticipated to significantly (and positively) influence health outcomes associated with occupational, environmental and clinical exposure to chemicals/drugs. To achieve this vision, innovative strategies are needed to develop multiplex sensor platforms capable of quantifying individual and mixed exposures (i.e. systemic dose) by measuring biomarkers of dose and biological response in readily obtainable (non-invasive) biofluids. Secondly, the use of saliva (alternative to blood) for biomonitoring coupled with the ability to rapidly analyze multiple samples in real-time offers an innovative opportunity to revolutionize biomonitoring assessments. In this regard, the timing and number of samples taken for biomonitoring will not be limited as is currently the case. In addition, real-time analysis will facilitate identification of work practices or conditions that are contributing to increased exposures and will make possible a more rapid and successful intervention strategy. The initial development and application of computational models for evaluation of saliva/blood analyte concentration at anticipated exposure levels represents an important opportunity to establish the limits of quantification and robustness of multiplex sensor systems by exploiting a unique computational modeling framework. The use of these pharmacokinetic models will also enable prediction of an exposure dose based on the saliva/blood measurement. This novel strategy will result in a more accurate prediction of exposures and, once validated, can be employed to assess dosimetry to a broad range of chemicals in support of biomonitoring and epidemiology studies.

Keywords: Biomarkers; Computational modeling; Non-invasive; Sensors.

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Conflict of interest statement

Conflict of interest The authors have nothing to disclose.

Figures

Fig. 1
Fig. 1
Biomarkers of exposure and response have a potential broad range of occupational and environmental applications.
Fig. 2
Fig. 2
Sensor development strategy.
Fig. 3
Fig. 3
Salivary gland clearance model.
Fig. 4
Fig. 4
Non-invasive quantitative dosimetry.
See this image and copyright information in PMC

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