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. 2022 Aug 1:9:738904.
doi: 10.3389/fvets.2022.738904. eCollection 2022.

Prevalence of Multidrug-Resistant CTX-M Extended Spectrum Beta-Lactamase-Producing Escherichia coli From Different Bovine Faeces in China

Xiaojuan Wei  1   2   3 , Weiwei Wang  1   2   3 , Ningning Lu  1   2   3 , Lingyu Wu  1   2   3 , Zhen Dong  1   2   3 , Bing Li  1   2   3 , Xuzheng Zhou  1   2   3 , Fusheng Cheng  1   2   3 , Kairen Zhou  1   2   3 , Haijian Cheng  4 , Hongmei Shi  5 , Jiyu Zhang  1   2   3
Affiliations

Prevalence of Multidrug-Resistant CTX-M Extended Spectrum Beta-Lactamase-Producing Escherichia coli From Different Bovine Faeces in China

Xiaojuan Wei et al. Front Vet Sci. .

Erratum in

Abstract

CTX-M extended spectrum beta-lactamase-producing Escherichia coli cause severe health hazards in livestock breeding. To date, little is known about antibiotic resistance differences among bacterial isolates from yaks, cows, and beef cattle; therefore, the aims of this study were to analyse the prevalence of CTX-M-producing E. coli in yak, beef cattle, and dairy cattle feces from different provinces in China. A total of 790 fecal samples from yaks, beef cattle, and dairy cows were used. Among all the samples, 523 non duplicate E. coli isolates were identified, and 29.6% of samples harbored CTX-M producers. The results showed that these E. coli strains harbored 15 clusters of CTX-M genes: CTX-M-79, CTX-M-55, CTX-M-15, CTX-M-14, CTX-M-28, CTX-M-179, CTX-M-65, CTX-M-24, CTX-M-27, CTX-M-102, CTX-M-105, CTX-M-173, CTX-M-238, CTX-M-196, and CTX-M-10. The dominant resistance genes were CTX-M-15, CTX-M-14, and CTX-M-55. Moreover, the distribution of CTX-M genes was related to geographical region. Based on the above findings, we reasoned that bovines are potential reservoirs of antibiotic resistance, and this problem should be given adequate attention.

Keywords: E. coli; beef cattle; blaCTX-M; dairy cattle; feces; yak.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Map identification of sampling locations (Yellow is Xinjiang, green is Qinghai, blue is Gansu, red is Sichuan and purple is Shandong).
Figure 2
Figure 2
A heatmap of resistant phenotype percentage of E.coli isolation from different areas. The right side of the legend shows the color range of different R values. Species clustering trees are presented on the left side of the heat map.
Figure 3
Figure 3
Distribution of antibiotic resistant phenotypes in E. coli from Shandong Province.
Figure 4
Figure 4
Distribution of antibiotic resistant phenotypes in E. coli from Xinjiang.
Figure 5
Figure 5
Distribution of antibiotic resistant phenotypes in E. coli from Gansu.
Figure 6
Figure 6
Distribution of antibiotic resistant phenotypes in E. coli from Qinghai.
Figure 7
Figure 7
Distribution of antibiotic resistant phenotypes in E. coli from Sichuan.
Figure 8
Figure 8
Comparison of antibiotic resistance in E. coli from yaks in different areas.
Figure 9
Figure 9
MLST profiles of E.coli isolates. (A) group 2; (B) group 4; (C) group 7.
See this image and copyright information in PMC

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