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. 2022 Aug 1:14:955878.
doi: 10.3389/fnagi.2022.955878. eCollection 2022.

Association of vitamin E intake in diet and supplements with risk of dementia: A meta-analysis

Rangyin Zhao  1   2 , Xiaoyong Han  3 , Hongxia Zhang  2 , Jia Liu  2 , Min Zhang  2 , Weijing Zhao  2 , Shangrong Jiang  2 , Ruilin Li  4 , Hui Cai  5   6   7   8 , Hong You  2
Affiliations

Association of vitamin E intake in diet and supplements with risk of dementia: A meta-analysis

Rangyin Zhao et al. Front Aging Neurosci. .

Abstract

Background: Dementia is a chronic progressive neurodegenerative disease that can lead to disability and death in humans, but there is still no effective prevention and treatment. Due to the neuroprotective effects of vitamin E, a large number of researchers have explored whether vitamin E can reduce the risk of dementia. Some researchers believe that vitamin E can reduce the risk of dementia, while others hold the opposite conclusion. We therefore performed a meta-analysis to clarify the relationship between them.

Methods: We searched PubMed, Embase, and Web of Science databases for articles on the connection of dietary and supplementation vitamin E with dementia risk from inception through April 2022 using the main keywords "dementia," "Alzheimer's disease," "vitamin E," and "tocopherol," and used a random-utility model for pooled effect sizes. Odds ratios (OR) and 95% confidence intervals were derived using lower and higher doses as contrasts. Obtained data were shown and assessed using Stata12.0 free software.

Results: We included 15 articles in sum. Among them, there were nine articles containing AD. By comparing the highest intake with the lowest intake, Combined ORs for high intake were as follows: dementia (OR = 0.79, 95% CI 0.70-0.88 I 2 = 35.0%), Alzheimer's disease (OR = 0.78, 95% CI 0.64-0.94 I 2 = 36.9%). Subgroup analyses were also performed by study type, diet and supplementation, and NOS score.

Conclusions: High vitamin E intake from diet and supplements significantly reduces the risk of dementia and Alzheimer's disease.

Keywords: dementia; diet; meta-analysis; risk; supplements; vitamin E.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of this meta-analysis.
Figure 2
Figure 2
Forest plots and subgroup analysis plots of high intake of dietary or supplemental vitamin E and risk of dementia. (A) Forest plot. (B) Subgroup analysis by study type. (C) Subgroup analysis by diet and supplements. (D) Subgroup analysis by NOS quality score.
Figure 3
Figure 3
Forest plots and subgroup analysis plots of high intake of dietary or supplemental vitamin E and risk of AD. (A) Forest plot. (B) Subgroup analysis by study type. (C) Subgroup analysis by diet and supplements. (D) Subgroup analysis by NOS quality score.
Figure 4
Figure 4
Publication bias begg's funnel plot. (A) Funnel plot for combined dietary and supplement outcomes with dementia risk. (B) Funnel plot for combined dietary and supplement outcomes with AD risk.
Figure 5
Figure 5
Sensitivity analysis. (A) Sensitivity analysis of combined dietary and supplement use and risk of dementia. (B) Sensitivity analysis of combined dietary and supplement use and risk of AD.
See this image and copyright information in PMC

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References

    1. Ali A. A., Abd El-Fattah A. I., Abu-Elfotuh K., Elariny H. A. (2021). Natural antioxidants enhance the power of physical and mental activities versus risk factors inducing progression of Alzheimer's disease in rats. Int. Immunopharmacol. 96:107729. 10.1016/j.intimp.2021.107729 - DOI - PubMed
    1. Aoki S., Yamagishi K., Maruyama K., Kishida R., Ikeda A., Umesawa M., et al. . (2021). Dietary intake of tocopherols and risk of incident disabling dementia. Sci. Rep. 11:16429. 10.1038/s41598-021-95671-7 - DOI - PMC - PubMed
    1. Barberger-Gateau P., Raffaitin C., Letenneur L., Berr C., Tzourio C., Dartigues J. F., et al. . (2007). Dietary patterns and risk of dementia: the Three-City cohort study. Neurology 69, 1921–1930. 10.1212/01.wnl.0000278116.37320.52 - DOI - PubMed
    1. Basambombo L. L., Carmichael P. H., Côt,é S., Laurin D. (2017). Use of vitamin E, and C supplements for the prevention of cognitive decline. Ann. Pharmacother. 51, 118–124. 10.1177/1060028016673072 - DOI - PubMed
    1. Behl C., Davis J., Cole G. M., Schubert D. (1992). Vitamin E protects nerve cells from amyloid beta protein toxicity. Biochem. Biophys. Res. Commun. 186, 944–950. 10.1016/0006-291X(92)90837-B - DOI - PubMed

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