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Review
. 2022 Jun 19;12(6):779-786.
doi: 10.5498/wjp.v12.i6.779.

Role of high mobility group box protein 1 in depression: A mechanistic and therapeutic perspective

Shu Wang  1 , Yu-Guang Guan  2 , Yan-Hua Zhu  3 , Min-Zhong Wang  4
Affiliations
Review

Role of high mobility group box protein 1 in depression: A mechanistic and therapeutic perspective

Shu Wang et al. World J Psychiatry. .

Abstract

As a common and serious psychiatric disorder, depression significantly affects psychosocial functioning and quality of life. However, the mechanism of depression is still enigmatic and perplexing, which limits its precise and effective therapeutic methods. Recent studies demonstrated that neuroinflammation activation plays an important role in the pathophysiology of depression. In this respect, high mobility group box 1 (HMGB1) may be a possible signaling inducer of neuroinflammation and can be a potential mechanistic and therapeutic target for depression. Herein, we review recent studies on the mechanistic and therapeutic targets of HMGB1 in depression and propose potential perspectives on this topic.

Keywords: Depression; High mobility group box 1; Mechanism; Neuroinflammation; Perspective; Review.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Illustration of mechanistic and therapeutic perspective of high mobility group box 1 in depression. HMGB1: High mobility group box 1; TLRs: Toll-like receptors; RAGE: Receptors for advanced glycation end products; CXCR4: C-X-C motif chemokine receptor 4.
See this image and copyright information in PMC

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