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. 2022 Aug 8:2022:4764254.
doi: 10.1155/2022/4764254. eCollection 2022.

Effect of Roxadustat on Factors Associated with Renal Fibrosis and Efficacy

Fangfang Zheng  1 , Peng Zhang  1 , Mingzuo Zhao  2 , Jinna Wang  1 , Xiaohong Xu  3 , Chi Zhang  3 , Li Zhang  4
Affiliations

Effect of Roxadustat on Factors Associated with Renal Fibrosis and Efficacy

Fangfang Zheng et al. Comput Math Methods Med. .

Retraction in

Abstract

Objective: We investigated the effect of roxadustat on factors associated with renal fibrosis and efficacy. Methods. Sixty patients meeting the inclusion criteria between January 2021 and October 2021 were equally distributed into observation (roxadustat) group and control (Erythropoietin) group. Then, the expression of serum hypoxia-inducible factor 1-alpha (HIF-1α), transforming growth factor-β (TGF-β1), vascular endothelial growth factor (VEGF), fibronectin (FN), and collagen Ⅳ (C-IV) was compared at different time points (baseline, 2-week follow-up, and 4-week follow-up). The improvement degree of hemoglobin (Hb) and the change level of iron parameters and hepcidin were also compared between the two groups. Results. In the roxadustat group, the expression of HIF-1α at 2 weeks was significantly higher than the baseline and approached the baseline value at 4 weeks. At 4 weeks, TGF-β1 and FN expression was significantly lower than baseline. In addition, the improvement of Hb in the roxadustat group was significantly higher than that in the control group at 4 weeks, and the change of ferritin, transferrin, and hepcidin indexes from baseline was better than in the control group.

Conclusion: After giving roxadustat, it can change the expression of HIF-1α, TGF-β1, and FN. Its efficacy is superior to EPO, which is worthy of clinical application.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Patients characteristics.
Figure 2
Figure 2
The expression level of serum HIF-1α in patients. Note: ∗P < 0.01 vs. baseline.
Figure 3
Figure 3
Changes in expression of TGF-β1, FN, C-IV, and VEGF. Note: ∗P < 0.05 vs. baseline.
Figure 4
Figure 4
Hemoglobin levels. Comparison with baseline values, ∗P < 0.05.
See this image and copyright information in PMC

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