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Review
. 2022 Aug 1:13:945129.
doi: 10.3389/fimmu.2022.945129. eCollection 2022.

Natural medicines of targeted rheumatoid arthritis and its action mechanism

Xueling Liu  1 , Zhiguo Wang  2 , Hua Qian  3 , Wenhua Tao  3 , Ying Zhang  1 , Chunyan Hu  1 , Weiwei Mao  1 , Qi Guo  1
Affiliations
Review

Natural medicines of targeted rheumatoid arthritis and its action mechanism

Xueling Liu et al. Front Immunol. .

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease involving joints, with clinical manifestations of joint inflammation, bone damage and cartilage destruction, joint dysfunction and deformity, and extra-articular organ damage. As an important source of new drug molecules, natural medicines have many advantages, such as a wide range of biological effects and small toxic and side effects. They have become a hot spot for the vast number of researchers to study various diseases and develop therapeutic drugs. In recent years, the research of natural medicines in the treatment of RA has made remarkable achievements. These natural medicines mainly include flavonoids, polyphenols, alkaloids, glycosides and terpenes. Among them, resveratrol, icariin, epigallocatechin-3-gallate, ginsenoside, sinomenine, paeoniflorin, triptolide and paeoniflorin are star natural medicines for the treatment of RA. Its mechanism of treating RA mainly involves these aspects: anti-inflammation, anti-oxidation, immune regulation, pro-apoptosis, inhibition of angiogenesis, inhibition of osteoclastogenesis, inhibition of fibroblast-like synovial cell proliferation, migration and invasion. This review summarizes natural medicines with potential therapeutic effects on RA and briefly discusses their mechanisms of action against RA.

Keywords: alkaloids; autoimmune disease; flavonoids; glycosides; natural medicines; polyphenols; rheumatoid arthritis; terpenes.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The main mechanism of natural medicines acting on RA. ↑: increase, promote or up regulation; ↓: decrease, down regulation or inhibit; Blue arrow: inhibit.
See this image and copyright information in PMC

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