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Case Reports
. 2022 Aug 11;10(8):e6211.
doi: 10.1002/ccr3.6211. eCollection 2022 Aug.

Primary malignant epithelioid hemangioendothelioma of the pleura: A review and report of a novel case

Alireza Rezvani  1   2 , Reza Shahriarirad  2   3 , Amirhossein Erfani  2   3 , Keivan Ranjbar  2   3
Affiliations
Case Reports

Primary malignant epithelioid hemangioendothelioma of the pleura: A review and report of a novel case

Alireza Rezvani et al. Clin Case Rep. .

Abstract

Epithelioid hemangioendothelioma is considered an uncommon tumor originating from vascular tissues. Although this disease is an extremely rare malignant cancer, its pleural subtype is even less common. We discuss a 68-year-old man with isolated pleural epithelioid hemangioendothelioma, along with a literature review of all similar cases.

Keywords: case report; epithelioid hemangioendothelioma; pleura; review.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

FIGURE 1
FIGURE 1
Chest computerized tomography in favor of left‐sided pleural effusion and mass (demonstrated with yellow arrow)
FIGURE 2
FIGURE 2
Pathological evaluation of primary malignant epithelioid hemangioendothelioma of the pleura; (A) section of tumor which shows a spindle cell proliferation without nuclear atypia (H&E, ×200); (B) spindle cell proliferation with hemangiopericytoma like vessels (H&E, ×100); (C) Ki67 staining which shows a low proliferative index; (D) positive CD34 immunostaining
FIGURE 3
FIGURE 3
A hypermetabolic nodule in the right lower lobe, adjacent to oblique right fissure with SUV of 4.39 at maximum and hypermetabolic primary tumoral involvement in the right parietal and mediastinal pleura, along with malignant right effusion were noted. Diffuse irregular pleural thickening is noted on the right side, showing increased FDG activity (SUVmax: up to 7.98)
FIGURE 4
FIGURE 4
Frequency of primary pleural malignant epithelioid hemangioendothelioma from 1943 to 2019 based on published research
See this image and copyright information in PMC

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