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Meta-Analysis
. 2022 Aug 1:10:903547.
doi: 10.3389/fpubh.2022.903547. eCollection 2022.

Effect of vitamin D supplementation on the incidence and prognosis of depression: An updated meta-analysis based on randomized controlled trials

Fei Xie  1 , Tongmin Huang  2 , Dandi Lou  3 , Rongrong Fu  3 , Chaoxiong Ni  4 , Jiaze Hong  2 , Lingyan Ruan  1
Affiliations
Meta-Analysis

Effect of vitamin D supplementation on the incidence and prognosis of depression: An updated meta-analysis based on randomized controlled trials

Fei Xie et al. Front Public Health. .

Abstract

Background: There have been several controversies about the correlation between vitamin D and depression. This study aimed to investigate the relationship between vitamin D supplementation and the incidence and prognosis of depression and to analyze the latent effects of subgroups including population and supplement strategy.

Methods: A systematic search for articles before July 2021 in databases (PubMed, EMBASE, Web of Science, and the Cochrane Library) was conducted to investigate the effect of vitamin D supplementation on the incidence and prognosis of depression.

Results: This meta-analysis included 29 studies with 4,504 participants, indicating that the use of vitamin D was beneficial to a decline in the incidence of depression (SMD: -0.23) and improvement of depression treatment (SMD: -0.92). Subgroup analysis revealed that people with low vitamin D levels (<50 nmol/L) and females could notably benefit from vitamin D in both prevention and treatment of depression. The effects of vitamin D with a daily supplementary dose of >2,800 IU and intervention duration of ≥8 weeks were considered significant in both prevention and treatment analyses. Intervention duration ≤8 weeks was recognized as effective in the treatment group.

Conclusion: Our results demonstrate that vitamin D has a beneficial impact on both the incidence and the prognosis of depression. Whether suffering from depression or not, individuals with low vitamin D levels, dose >2,800 IU, intervention duration ≥8 weeks, and all females are most likely to benefit from vitamin D supplementation.

Keywords: depression; incidence; meta-analysis; prognosis; vitamin D supplementation.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram describing inclusion and exclusion criteria.
Figure 2
Figure 2
Forest plot of the correlation between vitamin D and the incidence of depression.
Figure 3
Figure 3
Forest plot of the correlation between vitamin D and the incidence of depression for population with low vitamin D levels (<50 nmol/L).
Figure 4
Figure 4
Forest plot of the correlation between supplementary doses of vitamin D and the incidence of depression. (A) low doses (≤2,800 IU/day); (B) high doses (>2,800 IU/day).
Figure 5
Figure 5
Forest plot of the correlation between vitamin D and the prognosis of depression.
Figure 6
Figure 6
Forest plot of the correlation between vitamin D and the prognosis of depression for patients with low vitamin D levels (<50 nmol/L).
Figure 7
Figure 7
Forest plot of the correlation between supplementary doses of vitamin D and the prognosis of depression. (A) low doses (≤2,800 IU/day); (B) high doses (>2,800 IU/day).
See this image and copyright information in PMC

References

    1. Moussavi S, Chatterji S, Verdes E, Tandon A, Patel V, Ustun B. Depression, chronic diseases, and decrements in health: results from the world health surveys. Lancet. (2007) 370:851–8. 10.1016/S0140-6736(07)61415-9 - DOI - PubMed
    1. Anglin RES, Samaan Z, Walter SD, McDonald SD. Vitamin D deficiency and depression in adults: systematic review and meta-analysis. Br J Psychiatry. (2013) 202:100–7. 10.1192/bjp.bp.111.106666 - DOI - PubMed
    1. Wang X, Cheng S, Xu H. Systematic review and meta-analysis of the relationship between sleep disorders and suicidal behaviour in patients with depression. BMC Psychiatry. (2019) 19:303. 10.1186/s12888-019-2302-5 - DOI - PMC - PubMed
    1. Stahl SM. Selecting an antidepressant by using mechanism of action to enhance efficacy and avoid side effects. J Clin Psychiatry. (1998) 59(Suppl. 18):23–9. - PubMed
    1. Sinyor M, Schaffer A, Levitt A. The sequenced treatment alternatives to relieve depression (STAR*D) trial: a review. Can J Psychiatry. (2010) 55:126–35. 10.1177/070674371005500303 - DOI - PubMed